Structural specializations for antigen uptake and processing in the digestive tract.
Structural specializations for antigen uptake and processing in the digestive tract.
复制标题
消化道中抗原摄取和加工的结构特化。
DOI：
10.1007/bf00197502
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Ermak,TH
中科院分区：
文献类型：
--
作者：
Owen,RL;Ermak,TH
结论上皮对抗原摄取的适应和淋巴器官的细胞结构根据整个粘膜特定部位的特征而不同，但都有利于抗原摄取。无论周围粘膜是如口咽中的复层鳞状上皮还是如肠中的柱状上皮，每个区域中的组织化淋巴组织都显示表面特化，其减少局部屏障并促进微生物、颗粒和大分子的接近和摄取。在淋巴组织中，这些位点中的每一个的细胞防御机制被排列用于局部遏制、抗原加工和免疫应答的启动。
ConclusionsEpithelial adaptations for antigen uptake and lymphoid organ cytoarchitecture differ according to the characteristics of specific sites throughout the mucosa but all facilitate antigen uptake. Whether surrounding mucosa is stratified squamous epithelium as in the oropharynx or columnar epithelium as in the intestine, organized lymphoid tissue in each area displays surface specializations which reduce local barriers and facilitate the approach and uptake of microorganisms, particles and macromolecules. In lymphoid tissue in each of these sites cellular defense mechanisms are arrayed for local containment, antigen processing and initiation of immune responses.