Case report: Stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue
Case report: Stimulation of puberty in a girl with chemo- and radiation therapy induced ovarian failure by transplantation of a small part of her frozen/thawed ovarian tissue
复制标题
DOI：
10.1016/j.ejca.2012.09.028
复制
发表时间：
2013-03-01
影响因子：
8.4
通讯作者：
Andersen, Claus Yding
中科院分区：
文献类型：
--
作者：
Ernst, Erik;Kjaersgaard, Mimi;Andersen, Claus Yding
研究目的：诱导青春期的冷冻/解冻的卵巢组织移植前收集的促性腺激素治疗cancer.Patients和方法：一个9岁的女孩尤文肉瘤有一个卵巢切除和冷冻保存化疗和放疗前。剩余卵巢的功能活动在治疗期间被破坏。四年半后，女孩仍处于青春期前，FSH水平处于绝经后。结果：移植后4个月FSH恢复到低水平，移植后4个月FSH恢复到低水平。在接下来的一年里，青春期逐渐进展到坦纳阶段B4和P3，并开始有规律的月经周期。然而，19个月后的功能的移植物ceasing.Conclusions：我们已经表明，第一次在一个女孩治疗癌症，移植的卵巢组织可以恢复功能和分泌雌二醇在足够的量来诱导青春期。此外，她的大部分卵巢组织仍处于冷冻状态，有可能支持成年后的生育能力。(C)2012爱思唯尔有限公司保留所有权利。
Aim of the Study: To induce puberty by transplantation of frozen/thawed ovarian tissue collected prior to gonadotoxic treatment for a cancer.Patients and Methods: A 9-year-old girl with Ewing sarcoma had one ovary excised and cryo-preserved prior to chemo-and radiotherapy. Functional activity of the remaining ovary was destroyed during treatment. Four and a half years later the girl remained pre-pubertal with postmenopausal levels of FSH. Two of ten pieces of frozen/thawed cortex were transplanted to the remaining ovary in order to stimulate puberty.Results: Four months after the transplantation FSH returned to low levels. During the following year puberty gradually progressed to Tanner stage B4 and P3 and regular menstrual cycles started. However, after 19 months the function of the graft ceased.Conclusions: We have shown for the first time in a girl treated for cancer that transplanted ovarian tissue can regain function and secrete estradiol in a sufficient amount to induce puberty. In addition, the majority of her ovarian tissue remains frozen with a possibility to support fertility in adult life. (C) 2012 Elsevier Ltd. All rights reserved.