Impact of age at first drink on vulnerability to alcohol-related problems: Testing the marker hypothesis in a prospective study of young adults
Impact of age at first drink on vulnerability to alcohol-related problems: Testing the marker hypothesis in a prospective study of young adults
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DOI：
10.1016/j.jpsychires.2009.02.006
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发表时间：
2009-10-01
影响因子：
4.8
通讯作者：
Laucht, Manfred
中科院分区：
文献类型：
--
作者：
Buchmann, Arlette F.;Schmid, Brigitte;Laucht, Manfred
有充分的证据表明，过早开始饮酒是后来出现酒精相关问题的危险因素。本研究的目的是检验这种关联是否可以通过共同的潜在易感性指标来解释，或者是否可以将开始饮酒的年龄视为后来饮酒行为的独立预测因素，从而表明潜在的因果关系。参与者来自一项前瞻性队列研究，该研究研究了从出生起跟踪的早期危险因素的长期结果。对 304 名参与者进行了结构化访谈，以评估首次饮酒的年龄和当前的饮酒行为。通过标准化家长访谈，在儿童时期反复收集有关危险因素的数据，包括早期家庭逆境、父母酗酒、儿童精神病理学和压力生活事件。此外，还考虑了基因型信息。结果证实了之前的研究表明，有害饮酒与青春期早期饮酒有关。 5-HTTLPR 基因型和先前外化症状的程度显着预测首次饮酒的年龄较小，这两个因素都与 19 岁时饮酒量的增加或有害饮酒有关。然而，即使在控制了这些潜在的解释因素后，开始饮酒的年龄较早仍然是青年期大量饮酒的有力预测因素。本纵向研究对现有文献进行了补充，表明早发-成人危险饮酒关联不能仅仅归因于本研究中检查的共同遗传和精神病理危险因素。 (C) 2009 Elsevier Ltd. 保留所有权利。
There is ample evidence that the early initiation of alcohol use is a risk factor for the development of later alcohol-related problems. The purpose of the current study was to examine whether this association can be explained by indicators of a common underlying susceptibility or whether age at drinking onset may be considered as an independent predictor of later drinking behavior, suggesting a potential causal relationship. Participants were drawn from a prospective cohort study of the long-term outcomes of early risk factors followed up from birth onwards. Structured interviews were administered to 304 participants to assess age at first drink and current drinking behavior. Data on risk factors, including early family adversity, parental alcohol use, childhood psychopathology and stressful life events, were repeatedly collected during childhood using standardized parent interviews. In addition, information on genotype was considered. Results confirmed previous work demonstrating that hazardous alcohol consumption is related to early-adolescent drinking onset. A younger age of first drink was significantly predicted by 5-HTTLPR genotype and the degree of preceding externalizing symptoms, and both factors were related to increased consumption or harmful alcohol use at age 19. However, even after controlling for these potential explanatory factors, earlier age at drinking onset remained a strong predictor of heavy alcohol consumption in young adulthood. The present longitudinal study adds to the current literature indicating that the early onset - adult hazardous drinking association cannot solely be attributed to shared genetic and psychopathologic risk factors as examined in this study. (C) 2009 Elsevier Ltd. All rights reserved.