CELL-MEDIATED LYMPHOLYSIS STUDIES IN RENAL-ALLOGRAFT RECIPIENTS
CELL-MEDIATED LYMPHOLYSIS STUDIES IN RENAL-ALLOGRAFT RECIPIENTS
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DOI：
10.1097/00007890-198103000-00014
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发表时间：
1981-01-01
期刊：
影响因子：
6.2
通讯作者：
VANROOD, JJ
中科院分区：
文献类型：
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作者：
GOULMY, E;PERSIJN, G;VANROOD, JJ
细胞介导淋巴溶解（CML）对肾供体脾细胞的反应性可能是体外同种移植物反应的良好相关性。试图确定不相关的供体-受体组合之间是否发生CML无反应性，如果发生，在什么条件下发生。在非排斥患者中，70%的非相关供体-受体组合发生CML无反应性，而所有排斥患者均发生CML反应性。无CML反应性的患者比有CML反应性的患者临床表现更好。同时研究HLA-A、B、DR配型、性别、移植前输血次数、现敏化程度等变量是否易导致供者特异性CML无反应性。供体和受体之间的性别和HLA-B抗原的相容性可能是这些因素。
Cell-mediated lympholysis (CML) reactivity against the splenocytes of the kidney donor might be a good in vitro correlate of the homograft reaction. An attempt was made to determine whether CML nonreactivity between unrelated donor-recipient combinations occurs and, if so, under what conditions. CML nonreactivity occurs between unrelated donor-recipient combinations in 70% of the nonrejecting patients, whereas all of the rejecting patients were CML reactive. Patients with CML nonreactivity did clinically well more frequently than those that were CML reactive. The question as to whether or not such variables as HLA-A, B, and DR match and sex, the number of pretransplant blood transfusions, and the degree of presensitization, etc. predispose to the development of donor-specific CML nonreactivity was studied as well. Sex and compatibility for HLA-B antigens between donor and recipient might be such factors.