CD46- and CD150-independent endothelial cell infection with wild-type measles viruses
CD46- and CD150-independent endothelial cell infection with wild-type measles viruses
复制标题
DOI：
10.1099/vir.0.18877-0
复制
发表时间：
2003-05-01
影响因子：
3.8
通讯作者：
Schneider-Schaulies, J
中科院分区：
文献类型：
--
作者：
Andres, O;Obojes, K;Schneider-Schaulies, J
麻疹病毒（MV）在急性或持续性感染期间感染皮肤、大脑和其他器官的内皮细胞。内皮细胞被认为在病毒从血液传播到周围组织的过程中起着重要作用。CD46和CD150（信号淋巴细胞激活分子，SLAM）已被描述为某些MV菌株的细胞受体。我们发现人脐静脉和脑微血管内皮细胞（HUVECs和HBMECs） cd46阳性，但不表达SLAM。野生型MV株在转染的中国仓鼠卵巢细胞表面不使用CD46作为受体，以菌株依赖的方式不同程度地感染HUVECs和hbmec。这种感染不受CD46抗体的抑制。这些数据表明，在人内皮细胞中存在另一种未知的MV摄取和传播受体。
Measles virus (MV) infects endothelial cells of the skin, the brain and other organs during acute or persistent infections. Endothelial cells are supposed to play an important role in virus spread from the blood stream to surrounding tissues. CD46 and CD150 (signalling lymphocytic activation molecule, SLAM) have been described as cellular receptors for certain MV strains. We found that human umbilical vein and brain microvascular endothelial cells (HUVECs and HBMECs) were CD46-positive, but did not express SLAM. Wild-type MV strains, which do not use CD46 as a receptor at the surface of transfected Chinese hamster ovary cells, infected HUVECs and HBMECs to varying extents in a strain-dependent way. This infection was not inhibited by antibodies to CD46. These data suggest the presence of an additional unidentified receptor for MV uptake and spread in human endothelial cells.