Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins.
Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins.
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DOI：
10.1007/978-3-319-11731-7_3
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发表时间：
2015-01-01
影响因子：
--
通讯作者：
Blatch, Gregory L
中科院分区：
文献类型：
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作者：
Baindur-Hudson, Swati;Edkins, Adrienne L;Blatch, Gregory L
Hsp70/Hsp90组织蛋白（Hop），也被称为应激诱导蛋白1 (STI1)，在健康和患病状态下的多种细胞功能受到了广泛关注。有大量证据表明，细胞内Hop是Hsp70和Hsp90主要伴侣蛋白的共同伴侣，在Hsp90客户蛋白的生产性折叠中发挥重要作用。因此，Hop参与了许多关键的信号通路，包括导致癌症的异常通路。然而，Hop也可以分泌，现在已经确定Hop也可以作为朊病毒蛋白PrP(C)的受体。细胞内和细胞外形式的Hop最有可能代表两种不同的亚型，尽管这些不同功能的分子决定因素尚未确定。也有越来越多的研究报告，啤酒花参与细胞活动，似乎独立于伴侣或PrP(C)。虽然Hop已被证明具有多种细胞功能，但其生物学功能仍然难以捉摸。然而，最近在哺乳动物中的敲除研究表明Hop在胚胎发育中起重要作用。本文综述了啤酒花最新的分子、细胞和生物学研究，批判性地评估了其在健康系统中的功能以及这种功能如何在疾病状态下适应。
The Hsp70/Hsp90 organising protein (Hop), also known as stress-inducible protein 1 (STI1), has received considerable attention for diverse cellular functions in both healthy and diseased states. There is extensive evidence that intracellular Hop is a co-chaperone of the major chaperones Hsp70 and Hsp90, playing an important role in the productive folding of Hsp90 client proteins. Consequently, Hop is implicated in a number of key signalling pathways, including aberrant pathways leading to cancer. However, Hop is also secreted and it is now well established that Hop also serves as a receptor for the prion protein, PrP(C). The intracellular and extracellular forms of Hop most likely represent two different isoforms, although the molecular determinants of these divergent functions are yet to be identified. There is also a growing body of research that reports the involvement of Hop in cellular activities that appear independent of either chaperones or PrP(C). While Hop has been shown to have various cellular functions, its biological function remains elusive. However, recent knockout studies in mammals suggest that Hop has an important role in embryonic development. This review provides a critical overview of the latest molecular, cellular and biological research on Hop, critically evaluating its function in healthy systems and how this function is adapted in diseases states.