Quantifying Chemical Composition and Reaction Kinetics of Individual Colloidally Dispersed Nanoparticles
Quantifying Chemical Composition and Reaction Kinetics of Individual Colloidally Dispersed Nanoparticles
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DOI：
10.1021/acs.nanolett.1c03752
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发表时间：
2021-12-28
期刊：
影响因子：
10.8
通讯作者：
Wilhelm, Stefan
中科院分区：
文献类型：
--
作者：
Donahue, Nathan D.;Kanapilly, Sandy;Wilhelm, Stefan
为了控制纳米颗粒的化学组成和功能，研究人员需要容易获得和经济的表征方法，以高通量提供单个纳米颗粒的定量原位分析。在这里，我们建立了双分析物单粒子电感耦合等离子体四极杆质谱，以量化单个胶体纳米粒子的化学组成和反应动力学。我们确定了两种不同的化学反应过程中的单个纳米颗粒质量和化学成分的变化：（i）纳米颗粒蚀刻和（ii）以300+纳米颗粒/分钟的速率在纳米颗粒上沉积元素。我们的结果揭示了单个纳米颗粒水平上化学反应的异质性。这项概念验证研究作为一个框架，使用常用的质谱仪定量了解单个纳米颗粒在化学反应过程中经历的物理化学性质的动态变化。这些方法将广泛授权和通知合成和开发更安全，更有效，更高效的纳米技术，使用具有定义功能的纳米粒子。
To control a nanoparticle's chemical composition and thus function, researchers require readily accessible and economical characterization methods that provide quantitative in situ analysis of individual nanoparticles with high throughput. Here, we established dual analyte single-particle inductively coupled plasma quadrupole mass spectrometry to quantify the chemical composition and reaction kinetics of individual colloidal nanoparticles. We determined the individual bimetallic nanoparticle mass and chemical composition changes during two different chemical reactions: (i) nanoparticle etching and (ii) element deposition on nanoparticles at a rate of 300+ nanoparticles/min. Our results revealed the heterogeneity of chemical reactions at the single nanoparticle level. This proof-of-concept study serves as a framework to quantitatively understand the dynamic changes of physicochemical properties that individual nanoparticles undergo during chemical reactions using a commonly available mass spectrometer. Such methods will broadly empower and inform the synthesis and development of safer, more effective, and more efficient nanotechnologies that use nanoparticles with defined functions.