Sleep and Executive Functioning in Pediatric Traumatic Brain Injury Survivors after Critical Care.
Sleep and Executive Functioning in Pediatric Traumatic Brain Injury Survivors after Critical Care.
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DOI：
10.3390/children9050748
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发表时间：
2022-05-19
期刊：
影响因子：
2.4
通讯作者：
Hall, Trevor A.
中科院分区：
文献类型：
--
作者：
Williams, Cydni N.;McEvoy, Cindy T.;Lim, Miranda M.;Shea, Steven A.;Kumar, Vivek;Nagarajan, Divya;Drury, Kurt;Rich-Wimmer, Natalia;Hall, Trevor A.
每年有50,000多名儿童因创伤性脑损伤(TBI)住院，并面临长期的认知障碍。超过50%的人会患上睡眠/清醒障碍(SWD)，这会影响大脑的发育和康复。我们假设SWD预示着出院后1-3个月患有脑外伤的3-18岁儿童的执行功能结果会更差。使用儿童睡眠障碍量表(t-Score≥60)定义SWD。结果包括来自执行功能行为评定表的全球执行综合(GEC，t-Score)、第二版和学龄前版本，以及通过主成分分析组合成神经认知指数(NCI，z-Score)的多目标执行功能评估。在控制协变量的情况下，多元线性回归评估SWD和执行功能结果之间的相关性。在131名儿童中，68%的儿童有临床意义的SWD，这与GEC(56vs.45)和NCI(−0.02vs.0.42p<；0.05)的中位数显著降低有关。在多变量分析中，当控制基线特征和损伤严重程度时，SWD与较差的GEC(β系数=7.8；95%可信区间=2.5，13.1)和较差的NCI(β系数=−0.4；95%可信区间=−0.8，−0.04)相关。颅脑损伤儿童的SWD与出院后执行功能结果较差相关，并可作为改善结果的可修改目标。
Over 50,000 children are hospitalized annually for traumatic brain injury (TBI) and face long-term cognitive morbidity. Over 50% develop sleep/wake disturbances (SWDs) that can affect brain development and healing. We hypothesized SWDs would portend worse executive function outcomes in children aged 3–18 years with TBI 1–3 months after hospital discharge. SWDs were defined using the Sleep Disturbances Scale for Children (t-scores ≥ 60). Outcomes included the Global Executive Composite (GEC, t-score) from the Behavior Rating Inventory of Executive Function, Second and Preschool Editions, and multiple objective executive function assessments combined through Principal Components Analysis into a Neurocognitive Index (NCI, z-score). Multiple linear regression evaluated associations between SWDs and executive function outcomes, controlling for covariates. Among 131 children, 68% had clinically significant SWDs, which were associated with significantly worse median scores on the GEC (56 vs. 45) and NCI (−0.02 vs. 0.42; both p < 0.05). When controlling for baseline characteristics and injury severity in multivariable analyses, SWDs were associated with worse GEC (β-coefficient = 7.8; 95% Confidence Interval = 2.5, 13.1), and worse NCI (β-coefficient = −0.4; 95% Confidence Interval = −0.8, −0.04). SWDs in children with TBI are associated with worse executive function outcomes after hospital discharge, and may serve as modifiable targets to improve outcomes.
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影响因子：
4.8
作者：
Bruni, O.;Russo, P. M.;Guidetti, V.
通讯作者：
Guidetti, V.
影响因子：
3.8
作者：
Dodd, Jonathan N.;Hall, Trevor A.;Piantino, Juan
通讯作者：
Piantino, Juan
DOI：
10.1097/00005373-197403000-00001
发表时间：
1974-01-01
影响因子：
--
作者：
BAKER, SP;ONEILL, B;LONG, WB
通讯作者：
LONG, WB
影响因子：
2.4
作者：
Fischer, Jesse T.;Hannay, H. Julia;Ewing-Cobbs, Linda
通讯作者：
Ewing-Cobbs, Linda
影响因子：
1.5
作者：
Gioia, GA;Isquith, PK
通讯作者：
Isquith, PK