A mild, nonbasic synthesis of thioethers. The copper-catalyzed coupling of boronic acids with N-thio(alkyl, aryl, heteroaryl)imides.
A mild, nonbasic synthesis of thioethers. The copper-catalyzed coupling of boronic acids with N-thio(alkyl, aryl, heteroaryl)imides.
复制标题
DOI：
10.1021/ol026948a
复制
发表时间：
2002-11
期刊：
影响因子：
5.2
通讯作者：
C. Savarin;J. Šrogl;L. S. Liebeskind
中科院分区：
文献类型：
--
作者：
C. Savarin;J. Šrogl;L. S. Liebeskind
[反应：见正文]描述了一种新的硫醚合成方法。硼酸在催化量的Cu(I)羧酸盐存在下与芳基、杂芳基和烷基n -硫酰亚胺反应，可获得优异的硫醚产率。该反应发生在没有碱的温和条件下（THF, 45-50℃，2.5-12 h），是已知硫醚合成方法的有趣补充。
[reaction: see text] A new synthesis of thioethers is described. The reaction of boronic acids with aryl, heteroaryl, and alkyl N-thioimides in the presence of catalytic quantities of a Cu(I) carboxylate affords good to excellent yields of thioethers. This reaction takes place in the absence of a base under mild conditions (THF, 45-50 degrees C, 2.5-12 h) and represents an interesting complement to known methods for thioether synthesis.