Viscerally obese women with normal body weight have greater brachial-ankle pulse wave velocity than nonviscerally obese women with excessive body weight
Viscerally obese women with normal body weight have greater brachial-ankle pulse wave velocity than nonviscerally obese women with excessive body weight
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DOI：
10.1111/j.1365-2265.2007.02780.x
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发表时间：
2007-04-01
影响因子：
3.2
通讯作者：
Lee, Duk-Chul
中科院分区：
文献类型：
--
作者：
Lee, Ji-Won;Lee, Hye-Ree;Lee, Duk-Chul
目的确认内脏肥胖和臂踝脉搏波速度（baPWV）的关联，并比较代谢指标和baPWV之间的个人谁有正常体重，但内脏肥胖和个人体重过重谁不内脏obesity.Patients和测量我们共招募了150名妇女，年龄在22至67岁。我们通过计算机断层扫描（CT）评估了身体成分，并根据内脏脂肪组织面积将研究人群分为四组（正常，正常体重但内脏肥胖，超重但非内脏肥胖，超重和内脏肥胖）。baPWV的测量，使用体积体积描记instrument.Results尽管较低水平的总体脂肪，女性谁有一个正常的体重，但内脏肥胖有较高的血浆甘油三酯水平和baPWV测量和更大的皮下脂肪面积（SFA）和大腿SFA比体重过重的女性谁不是内脏肥胖。校正年龄、平均血压（BP）、体重指数（BMI）、甘油三酯水平、空腹胰岛素水平和游离脂肪酸（FFA）水平后，baPWV与腹部内脏脂肪面积独立相关，ct测得的（P值= 0.001）。结论内脏性肥胖的正常体重女性的baPWV均值高于体重超标但非内脏性肥胖的女性内脏肥胖和腹部内脏脂肪是baPWV的独立因素。这些结果表明，内脏肥胖个体，即使是在正常BMI范围内，也需要早期检测和干预，以预防动脉粥样硬化和心血管疾病（CVD）。
Objective To confirm the association of visceral obesity and brachial-ankle pulse wave velocity (baPWV) and to compare metabolic indices and baPWV between individuals who have normal body weight but are viscerally obese and individuals with excessive body weight who are not viscerally obese.Patients and Measurements We recruited a total of 150 women, aged 22 to 67 years. We assessed body composition, measured by computed tomography (CT), and divided the study population into four groups, based on visceral adipose tissue area (normal, normal body weight but viscerally obese, excessive body weight but not viscerally obese, and excessive body weight and viscerally obese). The baPWV was measured, using a volume plethysmographic instrument.Results Despite lower levels of total body fat, the women who had a normal body weight but were viscerally obese had a higher plasma triglyceride level and baPWV measurement and greater subcutaneous fat area (SFA) and thigh SFA than the women with excessive body weight who were not viscerally obese. After adjustment for age, mean blood pressure (BP), body mass index (BMI), triglyceride levels, fasting insulin levels, and free fatty acid (FFA) levels, baPWV was independently correlated with abdominal visceral fat area, as measured by CT (P = 0.001).Conclusions Mean baPWV was higher in women with normal body weight who were viscerally obese than in women who had excessive body weight but were not viscerally obese, and abdominal visceral fat was an independent factor for baPWV. These results suggest that early detection and intervention in viscerally obese individuals, even those within a normal BMI range, could be needed to prevent atherosclerosis and cardiovascular disease (CVD).