Association between Nonalcoholic Fatty Liver Disease (NAFLD) and Osteoporotic Fracture in Middle-Aged and Elderly Chinese
Association between Nonalcoholic Fatty Liver Disease (NAFLD) and Osteoporotic Fracture in Middle-Aged and Elderly Chinese
复制标题
中国中老年人非酒精性脂肪肝（NAFLD）与骨质疏松性骨折的关系
DOI：
10.1210/jc.2011-3010
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发表时间：
2012-06-01
影响因子：
5.8
通讯作者：
Ning, Guang
中科院分区：
文献类型：
--
作者：
Li, Mian;Xu, Yu;Ning, Guang
背景：非酒精性脂肪性肝病(NAFLD)被认为是代谢综合征的一种肝脏表现，并与各种代谢异常有关，这可能与骨质疏松性骨折的风险增加有关。目的：本研究的目的是确定非酒精性脂肪肝是否与骨质疏松性骨折相关。设计、背景和研究对象：这是一项横断面研究，调查对象为中国上海市嘉定区7797名40岁及以上的成年人。主要观察指标：问卷调查、人体测量、实验室检查和肝脏超声检查。排除酒精滥用和其他肝病后，经肝脏超声诊断为NAFLD。通过面试者辅助问卷收集骨折病史。结果：在男性中，非酒精性脂肪性肝病患者骨质疏松性骨折的发生率显著高于非酒精性脂肪肝患者(3.6%vs.1.7%，P=0.003)，而女性则无明显差异(3.4vs.2.6%，P=0.14)。在控制了潜在的混杂因素后，非酒精性脂肪肝的存在与男性骨质疏松性骨折的风险增加显著相关(优势比2.53；95%可信区间1.26-5.07；P=0.009)。结论：NAFLD的存在与中国中老年男性骨质疏松性骨折的近期病史显著相关。(临床内分泌代谢酶97：2033-2038,2012)
Context: Nonalcoholic fatty liver disease (NAFLD) has been considered as a hepatic manifestation of the metabolic syndrome and is associated with various metabolic abnormalities, which may link to an increased risk of osteoporotic fracture. However, epidemiological studies investigating the association between NAFLD and osteoporotic fracture were not available.Objective: The objective of the study was to determine whether NAFLD associates with osteoporotic fracture.Design, Setting, and Participants: This was a cross-sectional study of 7797 Chinese adults aged 40 yr or older in the Jiading District, Shanghai, China.Main Outcome Measures: A questionnaire, anthropometric measurements, laboratory tests, and a hepatic ultrasonic examination were conducted. NAFLD was diagnosed by hepatic ultrasound after the exclusion of alcohol abuse and other liver diseases. A history of fractures was collected with an interviewer-assisted questionnaire. Osteoporotic fractures were defined as fractures that occurred due to low-trauma in 2 yr prior to the study.Results: Among men, the prevalence of osteoporotic fractures was significantly higher in those with NAFLD (3.6 vs. 1.7%, P = 0.003); however, no difference was found in women (3.4 vs. 2.6%, P = 0.14). The presence of NAFLD was significantly associated with increased odds of osteoporotic fracture among men (odds ratio 2.53; 95% confidence interval 1.26-5.07; P = 0.009) after controlling for potential confounders. The significant associations were not detected in women.Conclusions: The presence of NAFLD was significantly associated with a recent history of osteoporotic fracture in middle-aged and elderly Chinese men. (J Clin Endocrinol Metab 97: 2033-2038, 2012)