Symbiont-mediated immune priming in animals through an evolutionary lens
Symbiont-mediated immune priming in animals through an evolutionary lens
复制标题
通过进化视角观察动物共生体介导的免疫启动
DOI：
10.1099/mic.0.001181
复制
发表时间：
2022
期刊：
影响因子：
1.5
通讯作者：
King, Kayla C.
中科院分区：
文献类型：
--
作者：
Hoang, Kim L.;King, Kayla C.
保护性共生体可以通过几种机制保护宿主免受寄生虫的侵害，从直接干扰到调节宿主免疫，随后对宿主和寄生虫的适应性产生影响。虽然对共生介导的免疫启动（SMIP）的研究主要集中在生态影响和农业重要生物上，但SMIP的进化意义尚不清楚。在这里，我们回顾了最近在阐明SMIP发生的生态和分子机制方面取得的进展。我们利用目前的工作来讨论这种现象驱动宿主、寄生虫和共生体进化的潜力。我们还提出了一些方法，可以用来解决有关免疫启动对宿主-微生物动力学和种群结构的影响的问题。最后，由于SMIP中涉及的一些共生体的短暂性，我们从生态学和进化的角度讨论了保护性共生体的意义，以及这种相互作用如何影响共生的长期持久性。
Protective symbionts can defend hosts from parasites through several mechanisms, from direct interference to modulating host immunity, with subsequent effects on host and parasite fitness. While research on symbiont-mediated immune priming (SMIP) has focused on ecological impacts and agriculturally important organisms, the evolutionary implications of SMIP are less clear. Here, we review recent advances made in elucidating the ecological and molecular mechanisms by which SMIP occurs. We draw on current works to discuss the potential for this phenomenon to drive host, parasite, and symbiont evolution. We also suggest approaches that can be used to address questions regarding the impact of immune priming on host-microbe dynamics and population structures. Finally, due to the transient nature of some symbionts involved in SMIP, we discuss what it means to be a protective symbiont from ecological and evolutionary perspectives and how such interactions can affect long-term persistence of the symbiosis.