An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts.
An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts.
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DOI：
10.1093/gerona/62.2.149
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发表时间：
2007-02
期刊：
影响因子：
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通讯作者：
J. de Magalhães;Joana Cósta;G. Church
中科院分区：
文献类型：
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作者：
J. de Magalhães;Joana Cósta;G. Church
对衰老的比较研究往往很难解释，因为往往与长寿相关的因素不同。我们使用AnAge数据库来研究这些因素，特别是代谢和发育时间表，以前与脊椎动物物种的寿命有关。我们的研究结果表明，在校正体重和生育后，基础代谢率与真兽目或鸟类的寿命无关，尽管它与有袋动物的寿命和成熟时间呈负相关。我们证实了这一观点，即成熟时的年龄通常与成年人的寿命成正比，并表明，哺乳动物，如蝙蝠和灵长类动物，其身体大小的寿命更长，也往往有更长的发育时间。最后，哺乳动物的产后生长率与成年寿命呈负相关，但在鸟类中则不然。我们的工作提供了一个详细的观点，与物种寿命的影响，如何解释老龄化的比较研究。
Comparative studies of aging are often difficult to interpret because of the different factors that tend to correlate with longevity. We used the AnAge database to study these factors, particularly metabolism and developmental schedules, previously associated with longevity in vertebrate species. Our results show that, after correcting for body mass and phylogeny, basal metabolic rate does not correlate with longevity in eutherians or birds, although it negatively correlates with marsupial longevity and time to maturity. We confirm the idea that age at maturity is typically proportional to adult life span, and show that mammals that live longer for their body size, such as bats and primates, also tend to have a longer developmental time for their body size. Lastly, postnatal growth rates were negatively correlated with adult life span in mammals but not in birds. Our work provides a detailed view of factors related to species longevity with implications for how comparative studies of aging are interpreted.