Overall "gain" of the respiratory control system in normoxic humans awake and asleep.
Overall "gain" of the respiratory control system in normoxic humans awake and asleep.
复制标题
含氧量正常的人在清醒和睡眠状态下呼吸控制系统的总体“增益”。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
H. Kimura
中科院分区：
文献类型：
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作者：
Y. Honda;F. Hayashi;A. Yoshida;Y. Ohyabu;Y. Nishibayashi;H. Kimura
在常氧条件下，加入外部死腔，测定10名健康男性受试者的PCO 2-通气反应和CO2产生。呼吸控制系统的总体“增益”（G）由相应实验运行的肺泡CO2分压（PACO 2）下的CO2响应曲线（S）和代谢双曲线（SL）的斜率计算。结果表明：1）尽管在非快速眼动睡眠（NREM）期间通气量降低，但SL降低并不影响G值，但个体差异较大; 2）睡眠和清醒时外部死腔对PACO 2变化的影响程度相似; 3）上述实验诱导的PACO 2变化与G值预测值吻合较好。与一般观点相反，这些结果表明，在正常健康受试者的NREM睡眠期间，呼吸控制系统的总体增益通常不受抑制。
With the addition of external dead space in normoxia, PCO2-ventilation response and CO2 production were determined in 10 healthy male subjects. Overall "gain" (G) of the respiratory control system was calculated from the slope of the CO2-response curve (S) and that of the metabolic hyperbola (SL) at alveolar partial pressure of CO2 (PACO2) of the respective experimental run. We found that 1) despite the depression of ventilation during non-rapid-eye-movement (NREM) sleep, G was generally not changed due to decreased SL, although considerable individual variations were seen; 2) effects of external dead space on PACO2 change during sleep and wakefulness were similar in magnitude; and 3) the above PACO2 changes experimentally induced agreed well with the predicted values estimated from G. Contrary to general opinion, these results demonstrated that overall gain of the respiratory control system is generally not depressed during NREM sleep in normal healthy subjects.