Associations of long-term exposure to ambient fine particulate matter and nitrogen dioxide with lung function: A cross-sectional study in China
Associations of long-term exposure to ambient fine particulate matter and nitrogen dioxide with lung function: A cross-sectional study in China
复制标题
长期暴露于环境细颗粒物和二氧化氮与肺功能的关联：中国的横断面研究
DOI：
10.1016/j.envint.2020.105977
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发表时间：
2020-11-01
影响因子：
11.8
通讯作者：
Song, Yuanlin
中科院分区：
文献类型：
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作者：
Hou, Dongni;Ge, Yihui;Song, Yuanlin
背景：很少有研究评价环境空气污染暴露对肺功能的影响，特别是在空气污染水平较高的地区。目的：探讨上海市颗粒物年浓度与PM2.5和NO2与成人肺功能的关系。方法：对5276名20岁的常住居民进行调查。PM2.5和NO2的年住宅暴露量分别通过基于卫星的验证模型和土地利用回归模型进行了估计。结果：PM2.5和NO2暴露水平越高，用力肺活量(FVC)、吸气量(IC)和肺活量(VC)越低。年平均PM2.5值每增加10µg/m(3)，FVC降低45.83ml(95%CI：-82.59，-9.07)，预计FVC降低1.36(95%CI：-2.42，-0.29)，IC降低121.98 ml(95%CI：-164.38，-79.57)，VC降低89.12ml(95%CI：-124.94，-53.3)。对于NO2，年平均浓度每增加10微克/立方米，FVC降低26.65毫升(95%CI：-46.29，-7.00)，FVC%PRAD降低0.70(95%CI：-1.27，0.13)，IC降低65.26毫升(95%CI：-87.76，-42.76)，VC降低45.88毫升(95%CI：-65.03，-26.73)。PM2.5和NO2分别为-0.74ml(95%CI：-17.13，15.65)和0.01%(95%CI：-0.58，0.61)，差异无统计学意义。分层分析显示，PM2.5在健康人群中的估计影响比COPD患者更大。肥胖的人更容易受到PM2.5和NO2对肺功能的不利影响。受教育程度未显示或仅有微弱证据表明空气污染与肺功能之间的关系改变。结论：在本研究中，长期暴露于环境空气污染物与肺功能损害显著相关，呈现限制性呼吸模式。
Background: Few studies have evaluated the effects of ambient air pollution exposure on lung function, especially in areas with high air pollution levels.Objectives: To investigate the associations of annual concentrations of particulate matter with diameters < 2.5 mu m (PM2.5) and nitrogen dioxide (NO2) with adult lung function in Shanghai, China.Methods: We included 5276 permanent residents aged >= 20 years. Annual residential exposure to PM2.5 and NO2 was estimated by validated satellite-based and land use regression models, respectively. The effects of PM2.5 and NO2 on lung function were estimated separately using multivariable linear regression, adjusting for potential confounders.Results: Higher exposure to PM2.5 and NO2 was significantly associated with lower forced vital capacity (FVC), inspiration capacity (IC), and vital capacity (VC). An increase of 10 mu g/m(3) in the annual average PM2.5 exposure was associated with a 45.83 ml (95% CI: -82.59, -9.07) lower FVC, 1.36 (95% CI: -2.42, -0.29) lower FVC of % predicted (FVC%pred), 121.98 ml (95% CI: -164.38, -79.57) lower IC, and 89.12 ml (95% CI -124.94, -53.3) lower VC. For NO2, an increase of 10 mu g/m3 in the annual average concentration was associated with 26.65 ml (95% CI: -46.29, -7.00) lower FVC, 0.70 (95% CI: -1.27, 0.13) lower FVC%pred, 65.26 ml (95% CI: -87.76, -42.76) lower IC, and 45.88 ml (95% CI: -65.03, -26.73) lower VC. The estimated effects on FEV1 were -10.25 ml (95% CI: -40.92, 20.42) and -0.29% (95% CI: -1.40, 0.82) per 10 mu g/m(3) increase in PM2.5 and -0.74 ml (95% CI: -17.13, 15.65) and 0.01% (95% CI: -0.58, 0.61) per 10 mu g/m(3) increase in NO2, which were not statistically significant. Stratified analysis showed that the estimated effects of PM2.5 were greater in the healthy subgroup than the COPD patients. Obese individuals were more susceptible to adverse effects of PM2.5 and NO2 on lung function. Education level showed no or only weak evidence of modification of the associations between air pollution and lung function.Conclusion: In this study, long-term exposure to ambient air pollutants was significantly associated with impaired lung function, presenting as restrictive ventilatory patterns.