Relationship among mediators, inflammation, and volume history with antigen versus hyperpnea challenge in guinea pigs.
Relationship among mediators, inflammation, and volume history with antigen versus hyperpnea challenge in guinea pigs.
复制标题
豚鼠介质、炎症和容量史与抗原与呼吸过度激发之间的关系。
DOI：
10.1164/ajrccm/146.5_pt_1.1315
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
IngramJr,RH
中科院分区：
文献类型：
--
作者：
Ingenito,EP;Godleski,JJ;Pliss,LB;Pichurko,BM;IngramJr,RH
机械通气性瘫痪豚鼠在等张高呼吸或抗原激发条件下收缩程度相似，表现出明显不同的肺阻力(RL)容量史对深呼吸的反应。我们比较了抗原收缩(AC)、高呼吸(HC)和对照组豚鼠的支气管肺泡灌洗液(SAL)介质谱、SAL总蛋白浓度和组织病理学，以确定峰值收缩附近的容量历史模式是否与特定的肺介质模式、微血管渗漏指数或组织炎症程度有关。乙酰甲胆碱收缩
Paralyzed mechanically ventilated guinea pigs constricted to a similar degree by either isocapnic hyperpnea or antigen challenge display significantly different lung resistance (RL) volume history responses to a deep breath. Wecompared bronchoalveolar lavage (SAL) mediator profiles, SAL total protein concentrations, and tissue histopathology of antigen-constricted (AC), hyperpnea-constricted (HC), and control guinea pigs to determine whether patterns of volume history near peak constriction could be related to specific patterns of lung mediators, indices of microvascular leakage, or severity of tissue Inflammation assessed pathologically. Methacholine constricted