Functional mapping of human brain in olfactory processing: A PET study
Functional mapping of human brain in olfactory processing: A PET study
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DOI：
10.1152/jn.2000.84.3.1656
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发表时间：
2000-09-01
影响因子：
2.5
通讯作者：
Fukuda, H
中科院分区：
文献类型：
--
作者：
Qureshy, A;Kawashima, R;Fukuda, H
这项研究描述了嗅觉和视觉命名和匹配在人类的功能解剖，使用正电子发射断层扫描（PET）。8名正常志愿者分别接受了一个无嗅觉或视觉刺激的基线控制任务、一个无认知的简单嗅觉和视觉刺激的控制任务、一组嗅觉和视觉命名任务以及一组嗅觉和视觉匹配任务。在嗅觉命名任务（ON）中，来自熟悉物品的气味与一些口头标签相关联，被命名。因此，它需要长期的嗅觉记忆提取刺激识别。嗅觉匹配任务（OM）涉及区分最近编码的不熟悉的气味从顺序呈现的一组不熟悉的气味。这需要短期嗅觉记忆提取刺激分化。简单的嗅觉和视觉刺激导致左侧眶额区、右侧梨状皮质和双侧枕叶皮质的激活。在嗅觉命名过程中，左侧楔叶、右侧前扣带回、左侧小脑和双侧小脑被激活。看来，识别气味来源的努力涉及语义分析和一定程度的心理意象。在嗅觉匹配过程中，在左侧楔叶和双侧小脑中观察到激活。这确定了在区分一种未标记的气味与其他气味时激活的大脑区域。在跨任务分析，该地区被发现是特定的嗅觉命名是左楔。我们的研究结果表明，在ON和OM任务的视觉皮层的明确招聘，最有可能与这些任务的图像组成部分。小脑在认知任务中的作用已经得到了认可，但这是第一个PET研究表明人类小脑也可能在认知嗅觉处理中发挥作用。
This study describes the functional anatomy of olfactory and visual naming and matching in humans, using positron emission tomography (PET). One baseline control task without olfactory or visual stimulation, one control task with simple olfactory and visual stimulation without cognition, one set of olfactory and visual naming tasks, and one set of olfactory and visual matching tasks were administered to eight normal volunteers. In the olfactory naming task (ON), odors from familiar items, associated with some verbal label, were to be named. Hence, it required long-term olfactory memory retrieval for stimulus recognition. The olfactory matching task (OM) involved differentiating a recently encoded unfamiliar odor from a sequentially presented group of unfamiliar odors. This required short-term olfactory memory retrieval for stimulus differentiation. The simple olfactory and visual stimulation resulted in activation of the left orbitofrontal region, the right piriform cortex, and the bilateral occipital cortex. During olfactory naming, activation was detected in the left cuneus, the right anterior cingulate gyrus, the left insula, and the cerebellum bilaterally. It appears that the effort to identify the origin of an odor involved semantic analysis and some degree of mental imagery. During olfactory matching, activation was observed in the left cuneus and the cerebellum bilaterally. This identified the brain areas activated during differentiation of one unlabeled odor from the others. In cross-task analysis, the region found to be specific for olfactory naming was the left cuneus. Our results show definite recruitment of the visual cortex in ON and OM tasks, most likely related to imagery component of these tasks. The cerebellar role in cognitive tasks has been recognized, but this is the first PET study that suggests that the human cerebellum may have a role in cognitive olfactory processing as well.