Data mining neocortical high-frequency oscillations in epilepsy and controls
Data mining neocortical high-frequency oscillations in epilepsy and controls
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DOI：
10.1093/brain/awr212
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发表时间：
2011-10-01
期刊：
影响因子：
14.5
通讯作者：
Worrell, Gregory A.
中科院分区：
文献类型：
--
作者：
Blanco, Justin A.;Stead, Matt;Worrell, Gregory A.
人类内侧颞叶局部场电位的瞬态高频（100- 500hz）振荡已被广泛研究。先前的研究报道，在内侧颞叶癫痫患者的发作区纹波（100-250 Hz）和快速纹波（250-500 Hz）振荡都增加。然而，对于它们在新皮层癫痫发作区的空间分布，以及它们在正常大脑中的患病率，我们所知相对较少。我们提出了一个定量分析高频振荡及其发生率在一组9例新皮质癫痫患者和2例对照患者无癫痫发作史。在癫痫研究中前所未有的数据集中，使用无监督方法自动检测和分类振荡，超过12tb的连续长期微观和宏观电极颅内记录，无需人工预处理，可以对振荡率进行无选择偏倚估计。有三个主要结果：(i)与快速纹波频率振荡集群（中位谱质心= 305 Hz）相比，中位谱质心= 137 Hz的纹波频率振荡集群在癫痫发作区增加的频率更高；（ii）我们发现癫痫患者控制区和非癫痫发作区新皮层的高频振荡率没有差异，尽管可能存在不同的潜在产生机制；（iii）虽然先前的研究表明，穿透薄壁的微电极记录的振荡频率峰值比穿透宏观电极高100-500 Hz，但在这里用于记录新皮层表面的外皮电极没有发现这一点。我们得出结论，纹波频率振荡的相对速率是癫痫新皮层的潜在生物标志物，但需要更大规模的前瞻性研究将高频振荡速率与癫痫发作区域、切除组织和手术结果相关联，以确定真正的预测值。
Transient high-frequency (100-500 Hz) oscillations of the local field potential have been studied extensively in human mesial temporal lobe. Previous studies report that both ripple (100-250 Hz) and fast ripple (250-500 Hz) oscillations are increased in the seizure-onset zone of patients with mesial temporal lobe epilepsy. Comparatively little is known, however, about their spatial distribution with respect to seizure-onset zone in neocortical epilepsy, or their prevalence in normal brain. We present a quantitative analysis of high-frequency oscillations and their rates of occurrence in a group of nine patients with neocortical epilepsy and two control patients with no history of seizures. Oscillations were automatically detected and classified using an unsupervised approach in a data set of unprecedented volume in epilepsy research, over 12 terabytes of continuous long-term micro- and macro-electrode intracranial recordings, without human preprocessing, enabling selection-bias-free estimates of oscillation rates. There are three main results: (i) a cluster of ripple frequency oscillations with median spectral centroid = 137 Hz is increased in the seizure-onset zone more frequently than a cluster of fast ripple frequency oscillations (median spectral centroid = 305 Hz); (ii) we found no difference in the rates of high frequency oscillations in control neocortex and the non-seizure-onset zone neocortex of patients with epilepsy, despite the possibility of different underlying mechanisms of generation; and (iii) while previous studies have demonstrated that oscillations recorded by parenchyma-penetrating micro-electrodes have higher peak 100-500 Hz frequencies than penetrating macro-electrodes, this was not found for the epipial electrodes used here to record from the neocortical surface. We conclude that the relative rate of ripple frequency oscillations is a potential biomarker for epileptic neocortex, but that larger prospective studies correlating high-frequency oscillations rates with seizure-onset zone, resected tissue and surgical outcome are required to determine the true predictive value.