Does body mass index differ between patients with Barrett's oesophagus and patients with chronic gastro-oesophageal reflux disease?
Does body mass index differ between patients with Barrett's oesophagus and patients with chronic gastro-oesophageal reflux disease?
复制标题
DOI：
10.1111/j.1365-2036.2007.03290.x
复制
发表时间：
2007-05-01
影响因子：
7.6
通讯作者：
Singh, G.
中科院分区：
文献类型：
--
作者：
Gerson, L. B.;Ullah, N.;Singh, G.
背景肥胖是胃食管反流病（GERD）的危险因素之一。目的进行一项前瞻性队列研究，以确定GERD患者和Barrett食管（BE）患者的体重指数（BMI）是否存在差异。吸烟和/或饮酒，以及GERD家族史。非糜烂性反流病患者进行了确证性24小时pH检测。年龄55.4 ± 14.2岁，74%为男性）进入研究，165例患者（22%，90%为男性，79%为高加索人）存在BE。GERD症状的平均持续时间为10.3 ± 0.4年（范围1-62岁），平均体重指数为27.8 +/- 0.2 kg/m（2）（范围15-55）与单纯GERD患者相比，BE患者更可能年龄较大，（P = 0.001）、男性（P < 0.001）、当前或既往吸烟者（P = 0.002）和GERD症状持续时间较长者（P < 0.001）。有和没有BE的患者的BMI没有显着差异。结论虽然肥胖是一个危险因素，胃食管反流病和BMI，BE患者并没有表现出增加BMI与慢性胃食管反流病患者相比。
Background Obesity has been demonstrated to be a risk factor for the development of gastro-oesophageal reflux disease (GERD).Aim To perform a prospective cohort study to determine whether there was a difference in body mass index (BMI) between patients with GERD and patients with Barrett's oesophagus (BE).Methods We prospectively enrolled patients undergoing endoscopic evaluation for GERD and collected information regarding BMI, tobacco and/or alcohol use, and family history of GERD. Patients with non-erosive reflux disease underwent confirmatory 24-h pH testing.Results Seven hundred and fifty one patients with GERD (mean +/- s.d. age of 55.4 +/- 14.2 years, 74% male) entered the study, and BE was present in 165 (22%, 90% male, 79% Caucasian) patients. The mean GERD symptom duration was 10.3 +/- 0.4 years (range 1-62 years) with a mean body mass index of 27.8 +/- 0.2 kg/m(2) (range 15-55) Compared with patients having GERD alone, patients with BE were more likely to be older (P = 0.001), male (P < 0.001), current or prior tobacco users (P = 0.002), and with greater duration of GERD symptoms (P < 0.001). There was no significant difference in the BMI for patients with and without BE.Conclusions While obesity is a risk factor for both GERD and BMI, patients with BE did not demonstrate increased BMI compared with patients having chronic GERD.