Wnt Signaling in Vertebrate Axis Specification
Wnt Signaling in Vertebrate Axis Specification
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DOI：
10.1101/cshperspect.a007955
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发表时间：
2013-01-01
影响因子：
7.2
通讯作者：
Sokol, Sergei Y.
中科院分区：
文献类型：
--
作者：
Hikasa, Hiroki;Sokol, Sergei Y.
Wnt通路是脊椎动物胚胎中控制细胞增殖、细胞命运和体轴决定的主要胚胎信号通路。卵子受精后不久，Wnt通路成分在微管依赖的背腹轴规范中发挥作用。在胚胎发育后期，该通路的另一个保守功能是指定前后轴。Wnt信号在爪蟾和斑马鱼胚胎中的双重作用在不同的发育阶段受到不同的Wnt靶基因的调控。本文综述了在脊椎动物轴向发育过程中不同信号分支的识别和特定通路靶点的识别方面的最新进展。
The Wnt pathway is a major embryonic signaling pathway that controls cell proliferation, cell fate, and body-axis determination in vertebrate embryos. Soon after egg fertilization, Wnt pathway components play a role in microtubule-dependent dorsoventral axis specification. Later in embryogenesis, another conserved function of the pathway is to specify the anteroposterior axis. The dual role of Wnt signaling in Xenopus and zebrafish embryos is regulated at different developmental stages by distinct sets of Wnt target genes. This review highlights recent progress in the discrimination of different signaling branches and the identification of specific pathway targets during vertebrate axial development.