Role of the HGF/c-MET tyrosine kinase inhibitors in metastasic melanoma.
Role of the HGF/c-MET tyrosine kinase inhibitors in metastasic melanoma.
复制标题
DOI：
10.1186/s12943-018-0795-z
复制
发表时间：
2018-02-19
期刊：
影响因子：
37.3
通讯作者：
Kucerova L
中科院分区：
文献类型：
--
作者：
Demkova L;Kucerova L
癌症患者的转移性疾病仍然是治疗上的挑战。转移过程涉及许多步骤，在此期间，恶性细胞成功激活细胞通路，促进在不利环境中的存活、在远离原发肿瘤的部位的植入和生长。已知黑色素瘤即使在疾病的早期阶段也具有产生转移的高倾向。本文就黑色素瘤转移的分子机制进行综述。然后，我们特别关注肝细胞生长因子（HGF）及其受体c-Met介导的信号通路，它们在生理过程中起重要作用，并与肿瘤发生有关。我们还关注c-Met受体酪氨酸激酶结构域的小分子抑制剂的作用及其对黑色素瘤细胞特性的影响。我们总结了最近的研究，其中涉及抑制HGF/c-Met信号转导，以减少黑色素瘤的生长和转移能力。
Metastatic disease in a cancer patient still remains a therapeutic challenge. Metastatic process involves many steps, during which malignant cells succeed to activate cellular pathways promoting survival in hostile environment, engraftment and growth at the distant site from the primary tumor. Melanoma is known for its high propensity to produce metastases even at the early stages of the disease. Here we summarize the most important molecular mechanisms which were associated with the melanoma metastasis. Then, we specifically focus on the signaling pathway mediated by hepatocyte growth factor (HGF) and its receptor c-Met, which play an important role during physiological processes and were been associated with tumorigenesis. We also focus on the effect of the small molecule inhibitors of the tyrosine kinase domain of the c-Met receptor and its effects on properties of melanoma cell. We summarize recent studies, which involved inhibition of the HGF/c-Met signaling in order to decrease melanoma growth and metastatic capacity.
登录
查看更多内容
影响因子：
37.3
作者：
Cao HH;Cheng CY;Su T;Fu XQ;Guo H;Li T;Tse AK;Kwan HY;Yu H;Yu ZL
通讯作者：
Yu ZL
影响因子：
8.8
作者：
Daud A;Kluger HM;Kurzrock R;Schimmoller F;Weitzman AL;Samuel TA;Moussa AH;Gordon MS;Shapiro GI
通讯作者：
Shapiro GI
DOI：
10.4137/tog.s30534
发表时间：
2015
期刊：
Translational oncogenomics
影响因子：
--
作者：
Garajová I;Giovannetti E;Biasco G;Peters GJ
通讯作者：
Peters GJ
影响因子：
8.4
作者：
Garbe, Claus;Peris, Ketty;Eggermont, Alexander M.
通讯作者：
Eggermont, Alexander M.
DOI：
10.1016/j.biocel.2014.01.009
发表时间：
2014-04-01
影响因子：
4
作者：
Barrow-McGee, Rachel;Kermorgant, Stephanie
通讯作者：
Kermorgant, Stephanie