Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements.
Correlating Local Volumetric Tissue Strains with Global Lung Mechanics Measurements.
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DOI：
10.3390/ma14020439
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发表时间：
2021-01-18
期刊：
影响因子：
--
通讯作者：
Wanelik K
中科院分区：
文献类型：
--
作者：
Arora H;Mitchell RL;Johnston R;Manolesos M;Howells D;Sherwood JM;Bodey AJ;Wanelik K
呼吸的机制是一个迷人而重要的过程。肺在长度尺度上具有复杂性和微妙的结构异质性，影响力学和功能。本研究建立了一个利用同步辐射微计算机断层扫描（SR-micro-CT）捕捉呼吸周期中肺泡变形的实验管道。对啮齿动物的肺进行机械通气，并在呼吸周期的不同时间点成像。记录压力-体积（P-V）特征，以捕捉实验期间整体肺力学行为的任何变化。从完整胸腔内的肺部收集了一系列断层摄影。利用数字体积相关（Digital volume correlation， DVC）从重建层析成像的时间序列计算肺泡水平的三维应变场。在呼吸周期中，突出了通气的区域差异，将肺组织内的局部菌株与全球通气测量值联系起来。局部应变达到约150%，而平均区域变形约为80-100%。在循环过程中观察到肺内空气的重新分布。相对通风较差的区域（与邻近区域相比变形较小）在实验后期变形更均匀（与邻近区域一致）。这种异质现象在日常呼吸中很常见。在病理性肺中，变形行为的一些不均匀性可能被夸大，导致功能不良或进一步损害。所提出的技术可以帮助表征给定病理的多尺度生物力学性质，以改善患者管理策略，同时考虑局部和全局肺力学。
The mechanics of breathing is a fascinating and vital process. The lung has complexities and subtle heterogeneities in structure across length scales that influence mechanics and function. This study establishes an experimental pipeline for capturing alveolar deformations during a respiratory cycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs were mechanically ventilated and imaged at various time points during the respiratory cycle. Pressure-Volume (P-V) characteristics were recorded to capture any changes in overall lung mechanical behaviour during the experiment. A sequence of tomograms was collected from the lungs within the intact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensional strain field at the alveolar level from the time sequence of reconstructed tomograms. Regional differences in ventilation were highlighted during the respiratory cycle, relating the local strains within the lung tissue to the global ventilation measurements. Strains locally reached approximately 150% compared to the averaged regional deformations of approximately 80–100%. Redistribution of air within the lungs was observed during cycling. Regions which were relatively poorly ventilated (low deformations compared to its neighbouring region) were deforming more uniformly at later stages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena are common in everyday breathing. In pathological lungs, some of these non-uniformities in deformation behaviour can become exaggerated, leading to poor function or further damage. The technique presented can help characterize the multiscale biomechanical nature of a given pathology to improve patient management strategies, considering both the local and global lung mechanics.
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DOI：
10.1016/j.compositesa.2011.07.018
发表时间：
2011-11-01
影响因子：
8.7
作者：
Arora, H.;Hooper, P. A.;Dear, J. P.
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
3.9
作者：
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通讯作者：
Tozzi, Gianluca
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
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