Improved bioresorbable microporous intravascular stents for gene therapy.
Improved bioresorbable microporous intravascular stents for gene therapy.
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DOI：
10.1097/00002480-199609000-00105
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发表时间：
1996-09
期刊：
影响因子：
4.2
通讯作者：
Y. Ye;C. Landau;R. S. Meidell;J. Willard;A. Moskowitz;S. Aziz;E. Carlisle;K. Nelson;R. Eberhart
中科院分区：
文献类型：
--
作者：
Y. Ye;C. Landau;R. S. Meidell;J. Willard;A. Moskowitz;S. Aziz;E. Carlisle;K. Nelson;R. Eberhart
许多中心正在开发药物吸入微孔支架，以促进球囊冠状动脉成形术后动脉壁的愈合。作者改进了1994年向该学会报告的可生物降解微孔支架的机械强度和储库性能。组合的管状/螺旋线圈支架容易通过漂浮/沉淀和铸造/缠绕技术制造。两阶段溶剂溶胀技术允许精确调节表面亲水/疏水平衡。这些发展允许药物容量提高7倍，而不显著改变机械性能。以这种方式修改的支架保持拉伸和压缩强度，并且适合于远程部署。这些改良支架的洗脱动力学表明它们适合于基因递送。成功的基因转移和透壁表达已被证明植入后的支架浸渍与重组腺病毒携带核定位β-半乳糖苷酶报告基因到兔颈动脉。这些研究表明，表面改性的，生物可吸收的聚合物支架最终可能是经皮腔内血运重建过程中基因转移的有用的替代装置。
Drug imbibing microporous stents are under development at a number of centers to enhance healing of the arterial wall after balloon coronary angioplasty procedures. The authors improved the mechanical strength and reservoir properties of a biodegradable microporous stent reported to this Society in 1994. A combined tubular/helical coil stent is readily fabricated by flotation/precipitation and casting/ winding techniques. A two stage solvent swelling technique allows precise adjustment of the surface hydrophilic/hydrophobic balance. These developments permit seven-fold improvement in drug capacity without significantly altering mechanical properties. Stents modified in this manner retain tensile and compressive strength and are suitable for remote deployment. Elution kinetics of these modified stents suggest they are suitable for gene delivery. Successful gene transfer and transmural expression have been demonstrated after implantation of stents impregnated with a recombinant adenovirus carrying a nuclear localizing beta-galactosidase reporter gene into rabbit carotid arteries. These studies suggest that surface modified, bioresorbable polymer stents ultimately may be useful adjunctive devices for gene transfer during percutaneous transluminal revascularization.