Spermatogonial stem cell transplantation and male infertility: Current status and future directions.
Spermatogonial stem cell transplantation and male infertility: Current status and future directions.
复制标题
DOI：
10.1016/j.aju.2017.11.015
复制
发表时间：
2018-03
影响因子：
1.5
通讯作者：
Schlegel PN
中科院分区：
文献类型：
--
作者：
Forbes CM;Flannigan R;Schlegel PN
总结精原干细胞（SSC）治疗的研究现状，重点是未来的方向，因为SSC显示出作为不育男性保持或启动生育能力的来源的希望。我们对精原干细胞移植治疗男性不育症的文献进行了检索。从1990年到2017年使用了搜索引擎PubMed和Google Scholar。检索词与精原干细胞治疗相关。对出版物的标题进行相关性筛选;如果相关，则阅读摘要，并对直接相关的原始研究的全文进行审查。总共有58篇论文被认为与本综述相关，并被纳入适当的副标题中。这篇综述讨论了各种技术，精原干细胞正在调查治疗形式的男性不育症。目前还没有证据支持SSC在人类中的临床应用。然而，精原干细胞在体外和体内发育方面的重大进展，包括分化为功能性生殖细胞，为未来的研究提供了谨慎乐观的理由。
To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. We performed a search for publications addressing spermatogonial stem cell transplantation in the treatment of male infertility. The search engines PubMed and Google Scholar were used from 1990 to 2017. Search terms were relevant for spermatogonial stem cell therapies. Titles of publications were screened for relevance; abstracts were read, if related and full papers were reviewed for directly pertinent original research. In all, 58 papers were found to be relevant to this review, and were included in appropriate subheadings. This review discusses the various techniques that SSCs are being investigated to treat forms of male infertility. Evidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research.