Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.
Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.
复制标题
DOI：
10.1245/s10434-012-2668-9
复制
发表时间：
2013-03
影响因子：
3.7
通讯作者：
DeMatteo RP
中科院分区：
文献类型：
--
作者：
Katz SC;Bamboat ZM;Maker AV;Shia J;Pillarisetty VG;Yopp AC;Hedvat CV;Gonen M;Jarnagin WR;Fong Y;D'Angelica MI;DeMatteo RP
结直肠癌肝转移瘤（CRCLM）的肿瘤浸润性淋巴细胞（TIL）计数预测切除后的生存。虽然CD4和CD8 T细胞与CRCLM切除术后的预后相关，但调节性T细胞（Treg）的作用尚未明确。采用组织微阵列免疫组化技术分析了1998年至2000年间188例CRCLM切除术患者的TIL。在控制既定预后因素的同时，确定TIL组成与预后的相关性。分析总T细胞（CD3）、辅助T细胞（CD4）、细胞毒性T细胞（CD8）和Treg （FoxP3）。所有患者的中位随访时间为40个月，幸存者为95个月。5年和10年的总生存率（OS）分别为40%和25%。CD4 T细胞计数与OS （p = 0.02）和无复发生存率（p = 0.04）相关。高数量的CD8 T细胞相对于总T细胞（CD8:CD3比率）预测更长的OS时间（p = 0.05）。Treg分析显示FoxP3:CD4 （p = 0.03）和FoxP3:CD8 （p = 0.05）比值高是较短OS的独立预测因子。临床风险评分（CRS）高的患者更可能有高数量的肿瘤内Treg，≥65岁的患者CRCLM T细胞浸润较弱。相对于CD4或CD8 T细胞的高Treg数量预示着不良的预后，提示FoxP3 + TIL具有免疫抑制作用。肿瘤内免疫反应是结直肠肝转移患者预后的独立预测因子。
Tumor-infiltrating lymphocyte (TIL) counts in colorectal cancer liver metastases (CRCLM) predict survival following resection. While CD4 and CD8 T cells have been correlated with outcome following CRCLM resection, the role of regulatory T cells (Treg) is not well defined. TIL in 188 patients who underwent CRCLM resection between 1998 and 2000 were analyzed by immunohistochemistry using tissue microarrays. Correlation between TIL composition and outcome was determined while controlling for established prognostic factors. Total T cells (CD3), helper T cells (CD4), cytotoxic T cells (CD8), and Treg (FoxP3) were analyzed. Median follow-up time was 40 months for all patients and 95 months for survivors. Overall survival (OS) at 5 and 10 years was 40 and 25 %, respectively. The CD4 T cell count correlated with OS (p = .02) and recurrencefree survival (p = .04). A high number of CD8 T cells relative to total T cells (CD8:CD3 ratio) predicted longer OS times (p = .05). Analysis of Treg revealed that high FoxP3:CD4 (p = .03) and FoxP3:CD8 (p = .05) ratios were independent predictors of shorter OS. Patients with a high clinical risk score (CRS) were more likely to have a high number of intratumoral Treg, and patients ≥65 years old had a less robust CRCLM T cell infiltration. A high number of Treg relative to CD4 or CD8 T cells predicted poor outcome, suggesting an immunosuppressive role for FoxP3 + TIL. The intratumoral immune response was an independent predictor of outcome in patients with colorectal liver metastases.
登录
查看更多内容
DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
8.8
作者：
通讯作者：
--
DOI：
10.1084/jem.20082205
发表时间：
2009-05-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hirschhorn-Cymerman D;Rizzuto GA;Merghoub T;Cohen AD;Avogadri F;Lesokhin AM;Weinberg AD;Wolchok JD;Houghton AN
通讯作者：
Houghton AN
影响因子：
32.4
作者：
Goubier, Anne;Dubois, Bertrand;Gheit, Hanane;Joubert, Grgoire;Villard-Truc, Florence;Asselin-Paturel, Carine;Trinchieri, Giorgio;Kaiserlian, Dominique
通讯作者：
Kaiserlian, Dominique
影响因子：
9
作者：
Fong, Y;Fortner, J;Blumgart, LH
通讯作者：
Blumgart, LH