The Content of Artemisinin in the Artemisia annua Tea Infusion
The Content of Artemisinin in the Artemisia annua Tea Infusion
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DOI：
10.1055/s-0030-1271065
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发表时间：
2011-10-01
期刊：
影响因子：
2.7
通讯作者：
Verpoorte, Robert
中科院分区：
文献类型：
--
作者：
van der Kooy, Frank;Verpoorte, Robert
用于治疗疟疾的药用植物黄花蒿的传统用途需要制备茶浸剂。在科学文献中，对茶冲剂中活性成分青蒿素的含量存在一些差异。由于这些差异，我们决定对不同方法制备的茶泡剂中的青蒿素进行定量。我们还研究了纯青蒿素在室温和100℃下的水溶性，并将其与植物材料中青蒿素的溶解度进行了比较。结果表明，萃取效率对温度非常敏感，萃取效率可达90%以上。我们还发现，提取物中的其他成分不会提高青蒿素的溶解度，但可能会形成过饱和的青蒿素溶液，该溶液至少在24小时内是稳定的。
The traditional use of themedicinal plant Artemisia annua for the treatment of malaria entails the preparation of a tea infusion. In the scientific literature there have been some discrepancies on the quantity of the active principle, artemisinin, in the tea infusion. Due to these discrepancies, we decided to quantify artemisinin in tea infusions prepared according to different methods. We also studied the water solubility of pure artemisinin at room temperature and at 100 C and compared it to the solubility of artemisinin from the plant material. We found that the extraction efficiency is very sensitive to temperature and that efficiencies of above 90% can be reached. We also showed that the solubility of artemisinin is not improved by other components in the extract but that a supersaturated solution of artemisinin might be formed, which is stable for at least 24 hours.