Intestinal Inflammation is Significantly Associated With Length Faltering in Preterm Infants at Neonatal Intensive Care Unit Discharge.
Intestinal Inflammation is Significantly Associated With Length Faltering in Preterm Infants at Neonatal Intensive Care Unit Discharge.
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DOI：
10.1097/mpg.0000000000003455
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发表时间：
2022-06-01
影响因子：
2.9
通讯作者：
Gregory, Katherine E.
中科院分区：
文献类型：
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作者：
Thai, Julie D.;Cherkerzian, Sara;Filatava, Evgenia J.;Luu, Ngan;Yamamoto, Hidemi S.;Fichorova, Raina N.;Belfort, Mandy B.;Gregory, Katherine E.
为评估肠道炎症指标，以胎龄(GA)和绝经后年龄(PMA)为指标，测定尿中肠道脂肪酸结合蛋白(IFABP)和粪便钙化保护素(FC)，以确定早产儿从出生到出院期间肠道炎症与生长发育之间的关系。我们假设肠道炎症与早产儿的不良生长有关。我们测定了72例住院早产儿(孕34周)的IFABP和Fc。我们使用Fenton生长参考值计算出生和出院时的体重和身长z分数。使用混合线性和Logistic回归模型评估平均IFABP或FC、出院时的生长z分数和生长迟缓(从出生到出院的体重或长度z分数差和lt；−0.8)之间的关系，调整了家庭内相关性和潜在的混杂因素：GA、性别、出生z分数、种族/民族和母亲年龄。早产儿的平均IFABP较大，且随胎龄增加而降低。平均Fc不受GA或PMA的影响。更高的平均IFABP和FC与较低的放电增长z分数和更大的增长停滞可能性相关，只有平均IFABP和放电长度z分数(β=−0.353，95%CI：−0.704，−0.002)和平均IFABP和长度抖动(OR1.99，p=0.018)显著相关。IFABP测量的肠道炎症与较低的长度z分数和出院时的长度抖动有关。预防肠道炎症的干预措施可能会改善早产儿的线性发育。
To assess intestinal inflammatory measures, urinary intestinal fatty acid binding protein (IFABP) and fecal calprotectin (FC) by gestational age (GA) and postmenstrual age (PMA) and determine the association between intestinal inflammation and growth in preterm infants from birth to hospital discharge. We hypothesized that intestinal inflammation is associated with adverse growth in preterm infants. We assayed repeated measures of IFABP and FC in 72 hospitalized preterm infants (<34 weeks’ gestation). We calculated weight and length z-scores at birth and discharge using the Fenton growth reference. Associations between mean IFABP or FC, growth z-scores at discharge, and growth faltering (weight or length z-score difference < −0.8 from birth to discharge) were assessed using mixed linear and logistic regression models, adjusted for intrafamilial correlation and potential confounders: GA, sex, birth z-score, race/ethnicity, and maternal age. Mean IFABP was greater among infants born at earlier GA and decreased with increasing PMA. Mean FC did not vary by GA or PMA. Higher mean IFABP and FC were associated with lower discharge growth z-scores and greater likelihood of growth faltering significant only for mean IFABP and discharge length z-score (β = −0.353, 95% CI: −0.704, −0.002) and mean IFABP and length faltering (OR 1.99, p=0.018). Intestinal inflammation, measured by IFABP, was associated with lower length z-scores and length faltering at discharge. Interventions to prevent intestinal inflammation may improve linear growth among preterm infants.