Sleep duration as a risk factor for the development of type 2 diabetes
Sleep duration as a risk factor for the development of type 2 diabetes
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DOI：
10.2337/diacare.29.03.06.dc05-0879
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发表时间：
2006-03-01
期刊：
影响因子：
16.2
通讯作者：
McKinlay, JB
中科院分区：
文献类型：
--
作者：
Yaggi, HK;Araujo, AB;McKinlay, JB
目的：短期部分睡眠限制导致葡萄糖耐受不良和胰岛素抵抗。本研究的目的是评估睡眠持续时间和临床diabetes.RESEARCH设计和方法的发病率之间的长期关系-一个队列的男性从马萨诸塞州男性老龄化研究没有糖尿病在基线（1987-1989年），直到2004年糖尿病的发展。每晚平均睡眠时间分为以下几类：8小时。计算每个睡眠时间类别中糖尿病发生的发生率和相对风险（RR）。那些报告每晚睡眠7小时的人作为参考组。多变量分析进行Poisson regression.RESULTS -男性报告睡眠时间短（每晚8小时睡眠）超过三倍的可能性发展为糖尿病在随访期间。在校正年龄、高血压、吸烟状况、自评健康状况、教育和腰围后，风险升高基本保持不变（8 h RR 1.95 [95%CI 0.95-4.01]）。当调整睾酮（1.51 [0.71-3.19] 8小时）时，两个极端睡眠组的RR发生了相当大的变化，这表明睡眠对糖尿病的影响可以通过内源性睾酮水平的变化来介导。睡眠时间可能是糖尿病的一个新的危险因素。
OBJECTIVE - Short-term partial sleep restriction results in glucose intolerance and insulin 0 resistance. The purpose of this study was to assess the long-term relationship between sleep duration and the incidence of clinical diabetes.RESEARCH DESIGN AND METHODS - A cohort of men from the Massachusetts Male Aging Study without diabetes at baseline (1987-1989) were followed until 2004 for the development of diabetes. Average number of hours of sleep per night Was grouped into the following categories: 8 h. Incidence rates and relative risks (RRs) were calculated for the development of diabetes in each sleep duration category. Those reporting 7 h of sleep per night served as the reference group. Multivariate analysis was performed using Poisson regression.RESULTS - Men reporting short sleep duration ( 8 h of sleep per night) were more than three times as likely to develop diabetes over the period of follow-up. Elevated risks remained essentially unchanged after adjustment for age, hypertension, smoking status, self-rated health status, education, and waist circumference (RR 1.95 [95% CI 0.95-4.01] for 8 h). RRs were altered considerably for the two extreme sleep groups when adjusted for testosterone (1.51 [0.71-3.19] for 8 h), suggesting that the effects of sleep on diabetes could be mediated via changes in endogenous testosterone levels.CONCLUSIONS - Short and long sleep durations increase the risk of developing diabetes, independent of confounding factors. Sleep duration may represent a novel risk factor for diabetes.