One-Step Formulation of Targeted Aggregation-Induced Emission Dots for Image-Guided Photodynamic Therapy of Cholangiocarcinoma
One-Step Formulation of Targeted Aggregation-Induced Emission Dots for Image-Guided Photodynamic Therapy of Cholangiocarcinoma
复制标题
用于胆管癌图像引导光动力治疗的靶向聚集诱导发射点的一步配制
DOI：
10.1021/acsnano.7b00312
复制
发表时间：
2017-04-01
期刊：
影响因子：
17.1
通讯作者：
Zheng, Qi Chang
中科院分区：
文献类型：
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作者：
Li, Min;Gao, Yang;Zheng, Qi Chang
光动力疗法（PDT）是一种姑息治疗技术，可以以微创的方式提高胆管癌（CC）患者的中位生存率。理想的光敏剂（PS）对于保证PDT的疗效至关重要。然而，传统的PS有一些明显的缺点，如缺乏特异性、在水介质中容易聚集等，限制了其在临床中的进一步应用。我们在此充分利用红色发射聚集诱导发射（AIE）PS，通过简单直接的一步策略制造整合素α（nu）β（3）靶向有机AIE点，用于图像引导PDT。获得的AIE点对CC表现出高度的特异性，并且在体外和体内均表现出优异的抗肿瘤效果。与传统的 PS 和之前报道的负载 PS 的纳米结构不同，当 AIE PS 分子处于聚集状态时，AIE 点不会遭受聚集引起的荧光猝灭和活性氧产生减少的影响。显着的抗肿瘤作用、良好的生物相容性和可忽略的毒性，使得AIE点在CC诊断和治疗的未来转化研究中充满希望。
Photodynamic therapy (PDT) is a palliative technique that can improve median survival with minimal invasion for cholangiocarcinoma (CC) patients. An ideal photosensitizer (PS) is critical to guarantee the efficacy of PDT. However, conventional PSs have some obvious drawbacks, such as lack of specificity and easy aggregation in aqueous media that limit their further application in the clinic. We herein fully take advantage of a red emissive aggregation induced emission (AIE) PS to fabricate integrin alpha(nu)beta(3) targeted organic AIE dots for image-guided PDT via a simple and straightforward one-step strategy. The obtained AIE dots exhibit high specificity to CC as well as excellent antitumor effect both in vitro and in vivo. Different from conventional PSs and previously reported PS-loaded nanostructures, the AIE dots do not suffer from aggregation caused fluorescence quenching and reduction in reactive oxygen species production when the AIE PS molecules are in an aggregated state. The significant antitumor effect, as well as good biocompatibility and negligible toxicity, makes the AIE, dots promising for future translational research in CC diagnosis and therapy.