Chronic low-level mercury exposure, BDNF polymorphism, and associations with cognitive and motor function
Chronic low-level mercury exposure, BDNF polymorphism, and associations with cognitive and motor function
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DOI：
10.1016/j.ntt.2005.08.001
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发表时间：
2005-11-01
影响因子：
2.9
通讯作者：
Garabedian, C
中科院分区：
文献类型：
--
作者：
Echeverria, D;Woods, JS;Garabedian, C
在存在和不存在脑源性神经营养因子（BDNF）多态性（Val 66 Met）的情况下，研究了元素汞（Hg-0）暴露对认知和运动的潜在影响。一组194名男性牙医（DD）和233名女性牙科助理（DA）的职业暴露于汞，没有肾脏或神经系统疾病的历史。急性接触是使用现场尿汞（HgU）浓度（平均值分别为3.32和1.98微克/升）和慢性职业接触指数（分别为26.3和14.9年，加权历史暴露）来测量的。DDs和DA的BDNF状态分别为68%和66%野生型，26%和30%单取代，5%和4%完全突变。分别评价DD和DA。回归分析控制了年龄、病前智力、饮酒和教育程度。
Potential cognitive and motor effects from exposure to elemental mercury (Hg-0) were examined in the presence and absence of a polymorphism (Val66Met) in brain-derived neurotrophic factor (BDNF). A group of 194 male dentists (DDs) and 233 female dental assistants (DAs) were occupationally exposed to mercury and had no history of kidney or nervous system disorders. Acute exposure was measured using spot urinary Hg (HgU) concentrations (average 3.32 and 1.98 mu g/l, respectively) and indices of chronic occupational exposure (26.3 and 14.9 years, respectively, weighted for historical exposures). The BDNF status was 68% and 66% wild type, 26% and 30% single substitution, and 5% and 4% full mutation for DDs and DAs, respectively. DDs and DAs were evaluated separately. Regression analyses controlled for age, premorbid intelligence, alcohol consumption, and education.Statistically significant adverse associations with HgU (p