Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care
Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care
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DOI：
10.1016/j.celrep.2021.109204
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发表时间：
2021-06-01
期刊：
影响因子：
8.8
通讯作者：
Kuroda, Kumi O.
中科院分区：
文献类型：
--
作者：
Yoshihara, Chihiro;Tokita, Kenichi;Kuroda, Kumi O.
母体哺乳动物表现出更强的照顾后代的动机，但其潜在的神经分子机制尚不清楚。在这里，我们报告了降钙素受体(Calcr)及其配体胰淀素在视前内侧区(MPOA)的不同神经元群中表达，并在母亲体内表达上调。父母照看激活的Calcr+MPOA神经元投射到躯体运动和单胺能脑干核团。逆行单突触示踪显示，在母亲中，对Calcr+神经元的传入发生了显著的改变。Calcr或Amylin基因表达的下调阻碍了冒险的产妇护理，Calcr+MPOA神经元的特异性沉默抑制了哺育行为，而药物遗传激活防止了处女男性的杀婴。这些数据表明，母体和异体母体的哺育行为都需要Calcr+MPOA神经元，并且MPOA中淀粉蛋白-Calcr信号的上调至少部分地介导了冒险的母体护理，可能是通过产后Calcr+神经元的改进连接。
Maternal mammals exhibit heightened motivation to care for offspring, but the underlying neuromolecular mechanisms have yet to be clarified. Here, we report that the calcitonin receptor (Calcr) and its ligand amylin are expressed in distinct neuronal populations in the medial preoptic area (MPOA) and are upregulated in mothers. Calcr+ MPOA neurons activated by parental care project to somatomotor and monoaminergic brainstem nuclei. Retrograde monosynaptic tracing reveals that significant modification of afferents to Calcr+ neurons occurs in mothers. Knockdown of either Calcr or amylin gene expression hampers risk-taking maternal care, and specific silencing of Calcr+ MPOA neurons inhibits nurturing behaviors, while pharmacogenetic activation prevents infanticide in virgin males. These data indicate that Calcr+ MPOA neurons are required for both maternal and allomaternal nurturing behaviors and that upregulation of amylin-Calcr signaling in the MPOA at least partially mediates risk-takingmaternal care, possibly via modified connectomics of Calcr+ neurons postpartum.