Focal adhesions, stress fibers and mechanical tension.
Focal adhesions, stress fibers and mechanical tension.
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DOI：
10.1016/j.yexcr.2015.10.029
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发表时间：
2016-04-10
影响因子：
3.7
通讯作者：
Guilluy C
中科院分区：
文献类型：
--
作者：
Burridge K;Guilluy C
应力纤维和粘着斑是产生、传递和感知机械张力的复杂蛋白质阵列。多年来积累的证据得出结论，应力纤维内产生的机械张力有助于应力纤维本身及其相关局灶性粘连的组装。然而，最近有几条证据反对这种模式。在这里，我们讨论的证据和反对的作用，机械张力驱动这些结构的组装。我们还考虑了它们的组装是如何受到细胞粘附的基质的刚性的影响。最后，我们讨论了最近发现的应力纤维和细胞核之间的联系，以及这些在细胞迁移和调节细胞核功能方面可能发挥的作用。
Stress fibers and focal adhesions are complex protein arrays that produce, transmit and sense mechanical tension. Evidence accumulated over many years led to the conclusion that mechanical tension generated within stress fibers contributes to the assembly of both stress fibers themselves and their associated focal adhesions. However, several lines of evidence have recently been presented against this model. Here we discuss the evidence for and against the role of mechanical tension in driving the assembly of these structures. We also consider how their assembly is influenced by the rigidity of the substratum to which cells are adhering. Finally, we discuss the recently identified connections between stress fibers and the nucleus, and the roles that these may play, both in cell migration and regulating nuclear function.