The effects of fear conditioning on cerebellar LTP and LTD.
The effects of fear conditioning on cerebellar LTP and LTD.
复制标题
恐惧调节对小脑 LTP 和 LTD 的影响。
DOI：
10.1111/j.1460-9568.2007.05632.x
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
Zhu L
Long‐term potentiation (LTP) and depression (LTD) at parallel fibre–Purkinje cell synapses have been describedin vitroin the cerebellar cortex, but the physiological roles of these two forms of plasticity have not been well defined. Here we show that, in cerebellar slices taken from rats that had undergone fear conditioning, there was a significant occlusion of electrically induced LTP at parallel fibre–Purkinje cell synapses. This effect was long‐lasting and related to associative processes, as LTP was not occluded in unpaired animals. Notably, in conditioned animals the LTP‐inducing protocol produced LTD in some cells instead of LTP. Conversely, synaptic depression induced by conjunctive stimulation of parallel fibers and climbing fibres was impaired in tissue taken immediately following aversive stimulation in both paired and unpaired subjects. This effect was not, however, long‐lasting as the incidence and extent of LTD returned to normal levels 24 h after behavioural testing. These findings suggest that LTP takes part in the mechanisms underlying aversive associative memories in the cerebellum.
