Sex differences in brain maturation during childhood and adolescence
Sex differences in brain maturation during childhood and adolescence
复制标题
DOI：
10.1093/cercor/11.6.552
复制
发表时间：
2001-06-01
期刊：
影响因子：
3.7
通讯作者：
Boring, AM
中科院分区：
文献类型：
--
作者：
De Bellis, MD;Keshavan, MS;Boring, AM
儿童和青少年时期的大脑发育以渐进髓鞘形成和退行修剪过程为特征。然而，大脑成熟的性别差异仍然知之甚少。应用磁共振成像技术对118例6-17岁健康儿童和青少年（男61例，女57例）的大脑灰质、白色物质体积和胼胝体面积与年龄、性别的关系进行了研究。性别组在年龄、惯用手、社会经济地位和全量表智商方面相似。与年龄相关的大脑灰质明显减少，白色物质体积和胼胝体面积明显增加，而颅内和大脑体积没有明显变化。大脑灰质和白色物质体积和胼胝体面积存在显著的性别-年龄相互作用。具体来说，男性有更显着的年龄相关的灰质减少和白质体积和胼胝体面积增加与女性相比。虽然这些数据来自横截面样本，需要在纵向研究中复制，但研究结果表明，大脑成熟过程中存在与年龄相关的性别差异。研究ega相关的脑修剪和髓鞘形成的性别差异可能有助于理解几种发育性神经精神障碍的机制。
Brain development during childhood and adolescence is characterized by both progressive myelination and regressive pruning processes. However, sex differences in brain maturation remain poorly understood. Magnetic resonance imaging was used to examine the relationships between age and sex with cerebral gray and white matter volumes and corpus callosal areas in 118 healthy children and adolescents (61 males and 57 females), aged 6-17 years. Gender groups were similar on measures of age, handedness, socioeconomic status and Full Scale IQ. Significant age-related reductions in cerebral gray and increases in white matter volumes and corpus callosal areas were evident, while intracranial and cerebral volumes did not change significantly. Significant sex by age interactions were seen for cerebral gray and white matter volumes and corpus callosal areas. Specifically, males had more prominent age-related gray matter decreases and whits matter volume and corpus callosal area increases compared with females. While these data are from a cross-sectional sample and need to be replicated in a longitudinal study, the findings suggest that there are age-related sex differences in brain maturational processes. The study of ega-related sex differences in cerebral pruning and myelination may aid in understanding the mechanism of several developmental neuropsychiatric disorders.