WALKING TRACK ANALYSIS - A LONG-TERM ASSESSMENT OF PERIPHERAL-NERVE RECOVERY
WALKING TRACK ANALYSIS - A LONG-TERM ASSESSMENT OF PERIPHERAL-NERVE RECOVERY
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DOI：
10.1097/00006534-199202000-00009
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发表时间：
1992-02-01
影响因子：
3.6
通讯作者：
HUNTER, DA
中科院分区：
文献类型：
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作者：
HARE, GMT;EVANS, PJ;HUNTER, DA
通过对大鼠的步行轨迹分析，评估了坐骨神经、胫神经和腓神经损伤后的功能恢复情况。内神经松解术不影响神经功能。挤压伤导致暂时但完全的功能丧失，并在4周后恢复到控制水平。神经横断导致功能完全丧失，无任何恢复迹象。神经修复后，功能恢复，在12周达到接近最佳的恢复。不同受累神经的功能恢复程度不同。坐骨神经恢复了41%的功能，而胫骨神经恢复了54%的功能。腓神经表现出最高程度的恢复，达到与对照组相似的功能水平。利用行走轨迹分析评估神经再生似乎是对传统组织学和电生理学方法的一个有价值的补充。
Functional recovery following sciatic, tibial, and peroncal nerve injury was assessed over a 1-year period using walking track analysis in the rat. Internal neurolysis did not affect nerve function. Crush injury induced a temporary, but complete, loss of function that recovered to control levels by 4 weeks. Nerve transection resulted in complete loss of function without any evidence of recovery. After nerve repair, functional recovery occurred, reaching near-optimal recovery by 12 weeks. The degree of functional recovery varied with the specific nerve involved. The sciatic nerve recovered 41 percent of function, whereas the tibial nerve recovered 54 percent of function. The peroneal nerve exhibited the highest degree of recovery, achieving functional levels similar to control values. Assessment of neural regeneration using walking track analysis appears to be a valuable addition to the traditional methods of histology and electrophysiology.