THE EFFECT OF RECOMBINATION BETWEEN THE X-CHROMOSOMES AND Y-CHROMOSOMES OF MAMMALS
THE EFFECT OF RECOMBINATION BETWEEN THE X-CHROMOSOMES AND Y-CHROMOSOMES OF MAMMALS
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DOI：
10.1111/j.1469-1809.1987.tb00865.x
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发表时间：
1987-01-01
影响因子：
1.9
通讯作者：
GOODFELLOW, PN
中科院分区：
文献类型：
--
作者：
BENGTSSON, BO;GOODFELLOW, PN
最近的分子分析证明了这样的假设：人类性染色体的部分内容是同源的，并且可以在雄性减数分裂中重组。通过考虑中性突变和随机遗传漂变对与性染色体非同源片段密切相关的基因座的联合效应，研究了这种重组的生物学后果，但该基因座以相当高的频率与它们重组。我们的模型预测，在没有选择的情况下，只有当重组率与突变率处于同一数量级或更小时，X和Y染色体上携带的基因之间的等位基因分化才会发生。类似地，只有当重组率小于突变的适应度优势时，对男性有利但对女性不利的突变才会增加Y染色体上的频率，而在X染色体上保持罕见。因此，X和Y染色体预计不会几乎所有同源部分都显示出任何遗传分化。仅当性染色体之间很少重组的基因座才会出现分歧。
Recent molecular analysis has proved the hypothesis that parts of the human sex chromosomes are homologous and can recombine in male meiosis. The biological consequences of this recombination have been investigated by considering the joint effect of neutral mutation and random genetic drift on a locus that is closely linked to the non‐homologous segments of the sex chromosomes, but which recombines with them in an appreciable frequency. Our model predicts that, in the absence of selection, allelic differentiation between genes carried on the X and on the Y chromosomes will develop only if the recombination rate is of the same order of magnitude as the mutation rate or smaller.Similarly, a mutation favourable in males but disadvantageous in females will increase in frequency on the Y chromosomes, while remaining rare on the X chromosomes, only if the recombination rate is smaller than the fitness advantage of the mutation.The X and Y chromosomes are, thus, not expected to show any genetic differentiation for almost all of their homologous parts. Divergence will occur only for loci thatveryrarely recombine between the sex chromosomes.