Genetic and environmental factors in complex diseases: The older Finnish twin cohort
Genetic and environmental factors in complex diseases: The older Finnish twin cohort
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DOI：
10.1375/136905202320906093
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发表时间：
2002-10-01
期刊：
影响因子：
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通讯作者：
Koskenvuo, M
中科院分区：
文献类型：
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作者：
Kaprio, J;Koskenvuo, M
在芬兰双胞胎队列的研究中，我们调查了芬兰常见、复杂疾病的遗传和环境决定因素及其行为风险因素，芬兰是一个遗传独特、文化同质的人群。我们建立了以下数据库：1)性别相似的双胞胎（13888对已知的合子）来自较老的双胞胎队列。自1975年以来，他们参加了邮件调查、亚样本的临床检查，并利用国家医疗登记册跟踪调查发病率；2) 1996年，双胞胎队列扩大到包括1938-1957年出生的异性双胞胎（约8000对）；第二，对青春期双胞胎及其家庭的新的纵向研究，形成了一个补充的，正在进行的研究基础，在随附的文章中有更详细的描述。遗传和环境的影响在人的一生中各不相同，只有对遗传信息数据集进行纵向研究才能对这种影响进行评价。最后，在表型丰富的家庭数据库中包含基于dna的遗传信息将为遗传流行病学和行为医学的研究提供独特的资源。
In studies on the Finnish Twin Cohort, we investigate genetic and environmental determinants of common, complex diseases, and their behavioral risk factors in Finland, a genetically unique and culturally homogenous population. We have formed the following databases: 1) Like-sexed twin pairs (13,888 pairs of known zygosity) form the older Twin Cohort. They have participated since 1975 in mail surveys, in clinical examinations for subsamples, and have been followed-up for morbidity using national medical registers; 2) The older Twin Cohort was expanded in 1996 to include opposite-sex pairs born 1938-1957 (c. 8000 pairs); 3) Two, new longitudinal studies of adolescent twins and their families, form a complementary, ongoing study base described in more detail in an accompanying article. Genetic and environmental effects vary over the life-span, and only longitudinal studies in genetically informative data sets permits the evaluation of such effects. Finally, the inclusion of DNA-based genetic information in a phenotypically rich family data base will offer a unique resource for research in genetic epidemiology and behavioral medicine.