Stress-related changes in proinflammatory cytokine production in wounds
Stress-related changes in proinflammatory cytokine production in wounds
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DOI：
10.1001/archpsyc.56.5.450
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发表时间：
1999-05-01
影响因子：
--
通讯作者：
Malarkey, WB
中科院分区：
文献类型：
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作者：
Glaser, R;Kiecolt-Glaser, PK;Malarkey, WB
背景：最近的几项研究表明，应激明显延迟伤口愈合。本研究评估了心理压力和促炎细胞因子的分泌在一个实际的伤口部位之间的关系，提供在体内的局部免疫反应的发展，是中央在伤口repair.Methods的早期阶段的数据：为了研究炎症的动力学，皮肤水泡引起的前臂上的36名妇女（平均年龄，57岁）通过抽吸。在去除泡罩顶之后，将塑料模板用胶带粘在臂上，并且将威尔斯孔用缓冲液中的70%自体血清填充。从泡罩室威尔斯5和24小时后wounding.Results：妇女与较高的感知压力分数表现出显着较低水平的2个关键细胞因子-白细胞介素1 α和白细胞介素8-在伤口部位。此外，受试者谁有低水平的两种细胞因子24小时后报告更多的压力和负面影响，他们有更高的唾液皮质醇水平比那些谁有高的细胞因子levels.Conclusion：一致的证据表明，应力延迟伤口愈合，这些数据表明一个可能的机制：心理压力有可测量的影响，促炎细胞因子的生产在当地的伤口环境。
Background: Several recent studies have shown that stress markedly delays wound healing. This study assessed the relationship between psychological stress and the secretion of proinflammatory cytokines at an actual wound site, providing in vivo data on the development of local immune responses that are central in the early stages of wound repair.Methods: To study the dynamics of inflammation, skin blisters were induced on the forearm of 36 women (mean age, 57 years) by suction. After the blister roofs were removed, a plastic template was taped to the arm, and wells were filled with 70% autologous serum in buffer. Specimens were aspirated from blister chamber wells 5 and 24 hours after wounding.Results: Women with higher perceived stress scores demonstrated significantly lower levels of 2 key cytokines-interleukin 1 alpha and interleukin 8-at wound sites. In addition, subjects who had low levels of both cytokines after 24 hours reported more stress and negative affect, and they had higher levels of salivary cortisol than those who had high cytokine levels.Conclusion: Consistent with the evidence that stress delays wound healing, these data suggest a possible mechanism: psychological stress has measurable effects on proinflammatory cytokine production in the local wound environment.