Electrolytes in stimulated whole saliva in individuals with hyposalivation of different origins
Electrolytes in stimulated whole saliva in individuals with hyposalivation of different origins
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DOI：
10.1016/s0003-9969(02)00200-5
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发表时间：
2003-05-01
影响因子：
3
通讯作者：
Wikström, M
中科院分区：
文献类型：
--
作者：
Almståhl, A;Wikström, M
有理由相信，唾液分泌速率的变化及其蛋白质和电解质组成的变化促进了口腔疾病相关微生物的生长。芥花中电解质的知识。因此，可能对设计口腔健康促进措施有价值。本研究分析了头颈部放射治疗（RT组）、原发性干燥综合征（pSS组）、抗精神病药物治疗（Neuro组）和不明原因药物治疗（unknown组）引起的低唾液分泌个体的全唾液电解质。与对照组相比，所有四组的碳酸氢盐浓度都显著降低。在正常情况下，碳酸氢盐浓度与唾液分泌率呈正相关，但神经组的碳酸氢盐浓度低于RT组和干燥组，尽管刺激分泌率大约是前者的两倍。此外，Neuro组的磷酸盐浓度最高。RT组和Sjogren组的钠浓度趋于增加。对于钾和钙，RT组的浓度明显高于其他低盐组和对照组。钙的大量增加和碳酸氢盐的减少表明腮腺的功能比其他唾液腺受到更大的影响。结果还表明，血浆对RT组和Sjogren组全唾液中电解质浓度的贡献。总之，在低唾液分泌的个体中，受刺激的全唾液中电解质的浓度似乎与低唾液分泌的原因关系更大，而不是唾液分泌率。2003爱思唯尔科学有限公司版权所有。
There are reasons to believe that changes in the secretion rate of saliva as well as changes in its protein and electrolyte composition promote the growth of micro-organisms associated with oral disorders. Knowledge of the electrolytes in the sativa. of those with hyposalivation might therefore be of value in designing oral health-promoting measures. In this study, electrolytes in stimulated whole saliva were analysed in individuals with hyposalivation due to radiation therapy in the head and neck region (RT group), primary Sjogren's syndrome (pSS group), neuroleptic: treatment (Neuro group), and to medication or of unknown origin (Unknown group). The bicarbonate concentration was significantly lower in all four hyposalivation groups compared with controls. The bicarbonate concentration, which in normal conditions is positively correlated with the salivary secretion rate, was lower in the Neuro group than in the RT and Sjogren's groups despite a stimulated secretion rate about twice as high. Furthermore, the Neuro group had the highest phosphate concentration. The RT and Sjogren's groups tended to have increased sodium concentrations. For potassium and calcium, the RT group had significantly higher concentrations than the other hyposalivation groups and the controls. The substantial increase in calcium and decrease in bicarbonate suggest that the function of the parotid glands is more affected than that of the other salivary glands. The results also indicate a contribution of plasma to the electrolyte concentrations determined in whole saliva in the RT and Sjogren's groups. In conclusion, in individuals with hyposalivation the concentrations of electrolytes in stimulated whole saliva seem to be more related to the reason for the hyposalivation than to the salivary secretion rate. (C) 2003 Elsevier Science Ltd. All rights reserved.