Pulsed Doppler assessment of left ventricular diastolic function in normal and cardiomyopathic cats
Pulsed Doppler assessment of left ventricular diastolic function in normal and cardiomyopathic cats
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DOI：
10.5326/15473317-35-4-285
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发表时间：
1999-07-01
影响因子：
1.3
通讯作者：
Schneider, JF
中科院分区：
文献类型：
--
作者：
Bright, JM;Herrtage, ME;Schneider, JF
对16只原发性肥厚性心肌病（HCM）猫左心室（LV）舒张功能进行了评价，采用脉冲多普勒（PD）评估传质血流和等容松弛时间。将获得的数据与12只健康的成年研究猫的数据进行比较。与正常猫相比，HCM组早期左室流入速度显著降低（p值小于0.05）（平均+/-标准误差[SE]，峰值速度为0.70+/-0.04米/秒比0.54+/-0.04米/秒，综合速度为0.48+/-0.08米/秒比0.37+/-0.03米/秒）；早期流入减速率降低(平均+/-SE， -12.0+/-1.0 m/s(2)，而-5.1+/-1.1 m/s(2))；延长等容弛豫时间（平均+/-SE， 45.7+/-3.3 ms vs 76.0+/-3.1 ms）；心房收缩流速增加（平均+/-SE，峰值流速分别为0.29+/-0.04 m/s和0.48+/-0.04 m/s，综合流速分别为0.21+/-0.03 m/s和0.34+/-0.03 m/s）。结果表明，PD提供了一种无创的方法来识别和量化HCM猫的功能性舒张损伤。
Left ventricular (LV) diastolic function was evaluated in 16 cats with primary hypertrophic cardiomyopathy (HCM) using pulsed Doppler (PD) assessment of transmitral flow and isovolumic relaxation time. Data obtained was compared to data from 12 healthy, adult, research cats. Compared to normal cats, the HCM group showed significantly (p value less than 0.05) reduced early LV inflow velocities (mean+/-standard error [SE], peak velocity of 0.70+/-0.04 mis versus 0.54+/-0.04 m/s and integrated velocity of 0.48+/-0.08 m/s versus 0.37+/-0.03 m/s); a reduced rate of deceleration of early inflow (mean+/-SE, -12.0+/-1.0 m/s(2)versus -5.1+/-1.1 m/s(2)); prolonged isovolumic relaxation time (mean+/-SE, 45.7+/-3.3 ms versus 76.0+/-3.1 ms); and increased atrial systolic flow velocities (mean+/-SE, peak velocity of 0.29+/-0.04 m/s versus 0.48+/-0.04 m/s and integrated velocity of 0.21+/-0.03 m/s versus 0.34+/-0.03 m/s). The results suggest that PD provides a noninvasive method of identifying and quantifying functional diastolic impairment in cats with HCM.