Non-Hodgkin's lymphoma in HIV-positive and HIV-negative homosexual men in the San Francisco Bay Area - Allergies, prior medication use, and sexual practices
Non-Hodgkin's lymphoma in HIV-positive and HIV-negative homosexual men in the San Francisco Bay Area - Allergies, prior medication use, and sexual practices
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DOI：
10.1097/00042560-199707010-00005
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发表时间：
1997-07-01
期刊：
影响因子：
--
通讯作者：
Lele, C
中科院分区：
文献类型：
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作者：
Holly, EA;Lele, C
1988 年至 1995 年间，在旧金山湾区进行了一项以人群为基础的病例对照研究，该研究对 1593 名 NHL 受试者和 2515 名对照受试者进行了分析，将生活方式、性史和病史特征作为非霍奇金淋巴瘤 (NHL) 的危险因素进行了分析。男同性恋者（312 名 NHL 受试者和 420 名对照受试者）的结果表明，HIV 感染与患非霍奇金淋巴瘤 (NHL) 的风险增加 20 倍相关。国家冰球联盟。在 HIV 阳性同性恋男性中，调整其他因素后，与 NHL 风险降低相关的因素包括 20 至 29 岁之间接受肛交的频率（1 至 9 次：OR = 0.63；大于或等于 10 次：OR = 0.37；趋势：p = 0.02）、对草、干草、树叶、植物和花粉过敏（OR = 0.35，CI = 0.19 至 0.64），蜜蜂或黄蜂蜇伤次数（1 至 3 次：OR = 0.65；大于或等于 4 次：OR = 0.56；趋势：p = 0.07），连续 4 周或更长时间使用泰胃美（西咪替丁）（OR = 0.39，CI = 0.17 至 0.89），接种流感疫苗（OR = 0.41，CI = 0.23 至 0.74），以及终生使用安非他明的频率（1 至 19 次：OR = 0.59；大于或等于 20 次：OR = 0.38；趋势：p = 0.003）。在 HIV 阴性同性恋男性中，调整其他因素后，与 NHL 状态相关的因素包括 20 至 29 岁之间接受肛交的频率（1 至 9 次：OR = 0.39；大于或等于 10 次：OR = 0.20；趋势：p = 0.001）、非药物过敏（OR = 0.43，CI = 0.21 至0.89），接种脊髓灰质炎疫苗
Lifestyle, sexual history, and medical history characteristics were analyzed as risk factors for non-Hodgkin's lymphoma (NHL) in a population-based case-control study of 1593 subjects with NHL and 2515 control subjects conducted in the San Francisco Bay Area between 1988 and 1995. The results for homosexual men, 312 with NHL and 420 control subjects, showed that HIV infection was associated with a 20-fold increased risk for NHL. Among HIV-positive homosexual men, after adjustment for other factors, those that were associated with a reduced risk for NHL were frequency of receptive anal intercourse between the ages of 20 and 29 (1 to 9 times: OR = 0.63; greater than or equal to 10 times: OR = 0.37; trend: p = 0.02), allergy to grass, hay, leaves, plants and pollen (OR = 0.35, CI = 0.19 to 0.64), number of bee or wasp stings (1 to 3 times: OR = 0.65; greater than or equal to 4 times: OR = 0.56; trend: p = 0.07), use of Tagamet (cimetidine) for 4 consecutive weeks or longer (OR = 0.39, CI = 0.17 to 0.89), vaccination against influenza (OR = 0.41, CI = 0.23 to 0.74), and lifetime frequency of amphetamine use (1 to 19 times: OR = 0.59; greater than or equal to 20 times: OR = 0.38; trend: p = 0.003). Among HIV-negative homosexual men, after adjustment for other factors, factors that were associated with NHL status were frequency of receptive anal intercourse between the ages of 20 and 29 (1 to 9 times: OR = 0.39; greater than or equal to 10 times: OR = 0.20; trend: p = 0.001), nonmedication allergies (OR = 0.43, CI = 0.21 to 0.89), vaccination against poliomyelitis at