Enhancement of cyclic AMP modulated salivary amylase secretion by protein kinase C activators.
Enhancement of cyclic AMP modulated salivary amylase secretion by protein kinase C activators.
复制标题
蛋白激酶 C 激活剂增强环 AMP 调节的唾液淀粉酶分泌。
DOI：
10.1016/0006-2952(88)90657-0
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发表时间：
1988
影响因子：
5.8
通讯作者：
Rubin,RP
中科院分区：
文献类型：
--
作者：
McKinney,JS;Rubin,RP
在离体大鼠腮腺细胞上研究了蛋白激酶C激活剂对异丙肾上腺素诱导的淀粉酶分泌的影响。佛波醇二丁酸酯预处理增强异丙肾上腺素诱导的淀粉酶分泌。佛波醇二丁酸酯的这种作用被二辛酰甘油或卡巴胆碱模仿。佛波醇二丁酸酯也增强分泌诱发的腺苷酸环化酶激活剂毛喉素和二丁酰cAMP。无论是佛波醇二丁酸酯，也没有卡巴胆碱增强异丙肾上腺素诱导的cAMP积累。本研究揭示了cAMP和蛋白激酶C之间的协调相互作用在一个步骤中的分泌机制远端cAMP的产生。
The effect of protein kinase C activators on isoproterenol-induced amylase secretion were investigated in isolated rat parotid cells. Pretreatment with phorbol dibutyrate potentiated isoproterenol-induced amylase secretion. This effect of phorbol dibutyrate was mimicked by dioctanoylglycerol or carbachol. Phorbol dibutyrate also potentiated secretion evoked by the adenylate cyclase activator forskolin and by dibutyryl cAMP. Neither phorbol dibutyrate nor carbachol enhanced isoproterenol-induced cAMP accumulation. The present study reveals a coordinate interaction between cAMP and protein kinase C at a step in the secretory mechanism distal to cAMP generation.