Head-direction cells in the rat posterior cortex
Head-direction cells in the rat posterior cortex
复制标题
大鼠后皮质中的头部方向细胞
DOI：
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发表时间：
1994
影响因子：
2
通讯作者：
Brace L. McNaughton
中科院分区：
文献类型：
--
作者：
Longtang L. Chen;Lie‐Huey Lin;C. Barnes;Brace L. McNaughton
本研究探讨了视觉和觉性线索对大鼠脑后皮质头向细胞空间调谐的影响。研究人员记录了动物在执行两种不同任务时的细胞外单单位反应，一种是在放射形臂迷宫中完成的空间工作记忆任务，另一种是在改进的“懒苏珊”平台上完成的被动旋转任务。视觉线索的影响是通过控制放置在迷宫周围的一张白色和三张黑色线索卡的位置来评估的。根据HD细胞在迷宫任务中对提示操作的反应，我们发现了三大类HD细胞。A型细胞（10/41）随着线索的旋转而旋转它们的首选方向。大多数HD细胞（B型，25/41）不受视觉线索旋转的影响，保持其既定的首选方向。C型细胞（6/41）对线索旋转表现出复杂的反应，其首选方向反映了a型和B型反应的组合或不可预测的反应。结果表明，方向性的内部表征可以通过视觉线索进行校准，并且一些助记过程可能参与了先前线索位置的注册。在迷宫任务和被动旋转任务中分别测试了11个细胞。大多数（9/11）在前一项任务中显示出明显的方向性，但在后一项任务中没有显示或显示出微弱的方向性，这表明运动相关的意识形态线索可能用于支持这些细胞的定向放电。只有两个细胞在两个任务中都表现出明显的方向性。他们建立的偏好方向不随迷宫任务的提示而旋转，但随被动旋转任务的提示而旋转。我们得出的结论是，这些皮质HD细胞中定向调谐的动态方面可能代表了角坐标表示的在线校准。
This study investigated the effects of visual and ideothetica cues on the spatial tuning of head-direction (HD) cells recorded in the rat posterior cortices. Extracellular, single unit responses were recorded from animals performing each of two different tasks, a spatial working memory task on a radial-arm maze and a passive rotation task on a modified “lazy Susan” platform. The influence of visual cues was assessed by manipulating the position of one white and three black cue-cards placed around the maze. We found three major categories of HD cells based on their response to cue manipulations in the maze tasks. Type A cells (10/41) rotated their preferred directions along with the rotation of the cues. The majority (type B, 25/41) of the HD cells were unaffected by the rotation of visual cues, maintaining their established preferred direction. Type C cells (6/41) showed complex responses to cue rotation, with the preferred direction reflecting either a combination of both type A and type B responses or an unpredictable response. The results indicate that the internal representation of directionality can be calibrated by visual cues and that some mnemonic processes may have been involved in the registration of the previous cue locations. Eleven cells were tested in both the maze task and the passive rotation task. Most (9/11) showed a significant directionality in the former task, but showed either no or weak directionality in the latter task, suggesting that movement-related ideothetic cues may be used in supporting the directional firing of these cells. Only two cells showed significant directionality in both tasks. Their established preferred directions did not rotate along with the cues in the maze task, but did rotate with the cues in the passive rotation task. We conclude that the dynamic aspect of the directional tuning in these cortical HD cells may represent on-line calibration of an angular coordinate representation.
影响因子：
13.9
作者：
Sparks,DL;Mays,LE
通讯作者：
Mays,LE
影响因子：
56.9
作者：
OHZAWA, I;DEANGELIS, GC;FREEMAN, RD
通讯作者：
FREEMAN, RD
影响因子：
56.9
作者：
ANDERSEN, RA;ESSICK, GK;SIEGEL, RM
通讯作者：
SIEGEL, RM