Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort
Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort
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DOI：
10.1097/00007435-200303000-00004
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发表时间：
2003-03-01
影响因子：
3.1
通讯作者：
Armenian, HK
中科院分区：
文献类型：
--
作者：
Bernstein, KT;Jacobson, LP;Armenian, HK
背景：人类疱疹病毒 8 型 (HHV-8) 在注射吸毒者 (IDU) 人群中的研究很少。目标：估计 2946 名 IDU 人群中 HHV-8 的血清阳性率和感染的危险因素。研究设计：在这项针对 390 名 IDU 的嵌套横断面研究中，利用裂解性 HHV-8 间接免疫荧光测定 (IFA) 来估计 HHV-8 的血清阳性率和感染的危险因素。 HHV-8 血清流行率。采用多变量逻辑回归来评估感染的危险因素。结果：1988 年检查的注射吸毒者中 HHV-8 血清阳性率为 11.5%（95% 置信区间，8.5-15.13）。该人群中的 HHV-8 血清流行率与女性（OR = 2.2；P = 0.080）、较大的体重指数（OR = 3.0；P = 0.053）和生殖器疣病史（OR = 4.0；P = 0.023）相关。注射任何药物超过每天一次都会对 HHV-8 血清阳性率产生反向影响（OR = 0.5；P = 0.085）。 结论：该人群中 HHV-8 的血清阳性率与一般人群中的相似，危险因素与性行为的关系比注射吸毒更一致。
Background: Human herpesvirus type 8 (HHV-8) has been infrequently studied in injecting drug user (IDU) populations.Goal: To estimate the seroprevalence of HHV-8 and risk factors for infection in a cohort of 2946 IDUs.Study Design: In this nested cross-sectional study of 390 IDUs, lytic HHV-8 indirect immunofluorescence assay (IFA) was utilized to estimate the HHV-8 seroprevalence. Multivariate logistic regression was used to assess risk factors for infection.Results: The HHV-8 seroprevalence among the IDUs examined in 1988 was 11.5% (95% confidence interval, 8.5-15.13). HHV-8 seroprevalence in this population was associated with being female (OR = 2.2; P = 0.080), having a larger body mass index (OR = 3.0; P = 0.053), and history of genital warts (OR = 4.0; P = 0.023). Injection of any drug more than daily exhibited an inverse effect on HHV-8 seropositivity (OR = 0.5; P = 0.085).Conclusion: The seroprevalence of HHV-8 in this population is similar to that seen in the general population, with risk factors being more consistent with sexual behaviors than injection drug use.