Selection for fitness at the individual or population levels: Modelling effects of genetic modifications in microalgae on productivity and environmental safety
Selection for fitness at the individual or population levels: Modelling effects of genetic modifications in microalgae on productivity and environmental safety
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DOI：
10.1016/j.jtbi.2009.12.021
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发表时间：
2010-04-07
影响因子：
2
通讯作者：
Shields, Robin J.
中科院分区：
文献类型：
--
作者：
Flynn, Kevin J.;Greenwell, H. Christopher;Shields, Robin J.
使用微藻的机制模型来探索改变微藻叶绿素含量和光合效率的影响，以优化商业生物质生产。这些模型显示，与未修改的配置相比，转基因配置的微藻生产力有可能提高 10 倍，同时还可以使用在较低稀释率下运行的更大光学深度的生物反应器。分析表明，对个体有利的性状（高 Chl:C(max)，即高触角尺寸）的自然选择与对群体水平上的生产最有利的性状（低 Chl:C(max)）的人工选择相冲突。这意味着转基因菌株而不是从自然界中选择的菌株将最有利于商业藻类生物燃料的生产。此外，根据改造的具体性质，逃逸的转基因藻类种群可能会很快被自然形式竞争，因为单独而言，高叶绿素：C 在弱光环境中是有益的。然而，与光系统能力的基因改造或与其他提高商业收益的选择过程相关的生化成分的变化仍然可能对这些生物体作为浮游动物猎物的价值产生不利影响，导致未来有害藻类的不必要的产生。 (C) 2010 Elsevier Ltd. 保留所有权利。
A mechanistic model of microalgae is used to explore the implications of modifying microalgal chlorophyll content and photosynthetic efficiency with an aim to optimising commercial biomass production. The models show the potential for a 10 fold increase in microalgae productivity in genetically modified versus unmodified configurations, while also enabling the use of bioreactors of greater optical depth operating at lower dilution rates. Analysis suggests that natural selection of a trait benefiting the individual (high Chl:C(max) i.e., high antennae size) conflicts with artificial selection of a trait (low Chl:C(max)) of most benefit to production at the population level. The implication is that GM strains rather than strains selected from nature will be most beneficial for commercial algal biofuels production. Further, escaped GM algae populations may, depending on the specific nature of the modification, be quickly out-competed by the natural forms because individually a high Chl:C is beneficial in low light environments. However, it remains possible that changes in biochemical composition associated with genetic modification of photosystem competence, or with other selection processes to enhance commercial gain, may adversely affect the value of such organisms as prey for zooplankton, leading to the unwanted generation of future harmful algae. (C) 2010 Elsevier Ltd. All rights reserved.