A role for WNT proteins in induction of dermomyotome
A role for WNT proteins in induction of dermomyotome
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DOI：
10.1006/dbio.1997.8713
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发表时间：
1997-11-01
影响因子：
2.7
通讯作者：
TessierLavigne, M
中科院分区：
文献类型：
--
作者：
Fan, CM;Lee, CS;TessierLavigne, M
体节形成骨节和皮肌节的背腹模式涉及源自体节周围组织的腹侧化和背侧化信号的拮抗作用。神经管的脊索和底板提供指导骨节发育的腹侧化信号，而表面外胚层和背侧神经管提供指导皮肌节发育的背侧化信号。有证据表明，Sonic Hedgehog 介导脊索和腹板的腹侧化效应，但尚未确定形成皮肌切开器模式的背侧化信号。记录的 Wnt1 和 Wnt3a 在背神经管中的表达以及 Wnt4 和 Wnt6 在皮肌切特化时表面外胚层中的表达促使我们研究 WNT 蛋白在皮肌切模式化中的参与。在这里，我们表明表达这些 WNT 家族成员的组织培养细胞可以维持和诱导前体中胚层外植体中的皮肌节标记物表达，支持 WNT 蛋白介导体节表面外胚层和背侧神经管的背侧化作用的假设。 (C) 1997 年学术出版社。
Dorsoventral patterning of somites into sclerotome and dermomyotome involves antagonistic actions of ventralizing and dorsalizing signals originating from tissues surrounding the somites. The notochord and the floor plate of the neural tube provide a ventralizing signal(s) directing sclerotome development, whereas the surface ectoderm and dorsal neural tube provide a dorsalizing signal(s) directing dermomyotome development. Evidence has been provided that Sonic Hedgehog mediates the ventralizing effects of notochord and boor plate, but the dorsalizing signal(s) that patterns the dermomyotome has not been identified. The documented expression of Wnt1 and Wnt3a in the dorsal neural tube and of Wnt4 and Wnt6 in the surface ectoderm at the time of dermomyotome specification prompted us to investigate the involvement of WNT proteins in patterning the dermomyotome. Here we show that tissue culture cells expressing these WNT family members can maintain and induce dermomyotome marker expression in presomitic mesoderm explants, supporting the hypothesis that WNT proteins mediate the dorsalizing effects of the surface ectoderm and dorsal neural tube on somites. (C) 1997 Academic Press.