SYNTHESIS AND CYTOTOXICITY OF SOME CYCLOMETALATED PALLADIUM COMPLEXES
SYNTHESIS AND CYTOTOXICITY OF SOME CYCLOMETALATED PALLADIUM COMPLEXES
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DOI：
10.1016/0162-0134(93)85023-2
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发表时间：
1993-02-01
影响因子：
3.9
通讯作者：
FRICKER, S
中科院分区：
文献类型：
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作者：
HIGGINS, JD;NEELY, L;FRICKER, S
通过相应的二聚体前体与各种胺的开桥反应，制备了几种单体环化钯配合物。通过元素分析和核磁共振氢谱对配合物进行了表征。络合物的通式可以给出为Pd（N-C）LX，其中（N-C）是通过胺和形式环化的Pd-C键作为螯合配体配位的芳族或脂族胺; L =胺，X =氯离子或乙酸根。还直接合成了一种基于2-苯基邻菲咯啉环钯化反应的独特配合物。筛选了一系列复合物对一组7种人肿瘤细胞系的细胞毒性。发现所有复合物在μ g/ml浓度下都具有细胞毒性（IC 50），而两种复合物也显示出一定的细胞毒性差异。
Several monomeric cyclometallated palladium complexes have been prepared by bridge opening reactions of their corresponding dimeric precursors with various amines. The complexes were characterized by elemental analyses and proton NMR spectroscopy. The general formula for the complexes can be given as Pd(N-C)LX where (N-C) is an aromatic or aliphatic amine coordinated as a chelating ligand through the amine and a formal cyclometallated Pd-C bond; L = amine, X = chloride or acetate. A unique complex based on the cyclopalladation of 2-phenyl phenanthroline was also prepared directly. The series of complexes was screened for cytotoxicity against a panel of seven human tumor cell lines. All complexes were found to be cytotoxic (IC50) at mug/ml concentrations, while two complexes also displayed some differential cytotoxicity.