Relationship Between Carbon Dioxide Levels and Reported Headaches on the International Space Station
Relationship Between Carbon Dioxide Levels and Reported Headaches on the International Space Station
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DOI：
10.1097/jom.0000000000000158
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发表时间：
2014-05-01
影响因子：
3.2
通讯作者：
Alexander, David
中科院分区：
文献类型：
--
作者：
Law, Jennifer;Van Baalen, Mary;Alexander, David
目的：由于国际空间站（ISS）上与CO2有关的症状的轶事报告，CO2和飞行中头痛之间的关系进行了analysed.Methods：头痛报告和CO2测量，算术平均值和单点最大值被确定为24小时和7天的时间。多重插补解决了缺失的数据，和logistic回归模型之间的关系CO2，头痛的概率，和covariates.Results：CO2水平，年龄在发射，飞行时间，和数据源显着相关头痛。二氧化碳每增加1毫米汞柱，船员报告头痛的几率就会增加一倍。为了保持头痛的风险低于1%，平均7天的CO2将需要保持低于2.5毫米汞柱（目前国际空间站范围：1至9毫米汞柱）。结论：虽然头痛的发病率不高，结果表明增加敏感性的生理影响的CO2在飞行中。
Objective: Because of anecdotal reports of CO2-related symptoms onboard the International Space Station (ISS), the relationship between CO2 and in-flight headaches was analyzed.Methods: Headache reports and CO2 measurements were obtained, and arithmetic means and single-point maxima were determined for 24-hour and 7-day periods. Multiple imputation addressed missing data, and logistic regression modeled the relationship between CO2, headache probability, and covariates.Results: CO2 level, age at launch, time in-flight, and data source were significantly associated with headache. For each 1-mm Hg increase in CO2, the odds of a crew member reporting a headache doubled. To keep the risk of headache below 1%, average 7-day CO2 would need to be maintained below 2.5 mm Hg (current ISS range: 1 to 9 mm Hg).Conclusions: Although headache incidence was not high, results suggest an increased susceptibility to physiological effects of CO2 in-flight.