Remodeling dynamics in the alveolar process in skeletally mature dogs
Remodeling dynamics in the alveolar process in skeletally mature dogs
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DOI：
10.1002/ar.a.20396
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发表时间：
2006-12-01
期刊：
影响因子：
--
通讯作者：
Li, Yan
中科院分区：
文献类型：
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作者：
Huja, Sarandeep S.;Fernandez, Soledad A.;Li, Yan
骨转换率可以通过代谢和机械需求改变。由于加载模式的差异，我们假设上颌骨和下颌骨牙槽突之间的骨重建率存在差异。此外，在犬科动物模型中，缺乏接触的牙齿的牙槽突（例如，第二前磨牙）将具有与具有功能接触的骨支撑牙齿不同的周转率（例如，第一磨牙）。给6只雄性成年犬一对钙黄绿素标记。处死后，制备代表两个颌骨前后位置的标本，通过组织形态学方法进行检查，以评估牙槽突中的骨体积/总体积（BV/TV; %）、骨体积（mm（2））、矿物质沉积率（MAR; μ m/天）和骨形成率（BFR;%/年）。颌内BV/TV差异无统计学意义（P> 0.05）。下颌骨牙槽突内的骨体积是上颌骨的2.8倍。下颌和前后位置之间的MAR无显著差异。然而，下颌骨的BFR显著（P <0.0001）大于上颌骨。前位置有较高的（P = 0.002）重塑比后位置在上颌骨，但不是在下颌骨。虽然有一个更大的骨量和下颌骨的重塑增加，没有重塑梯度在冠状根尖方向是明显的牙槽突。骨适应可能涉及骨转换、质量和结构的复杂相互作用。
Bone turnover rates can be altered by metabolic and mechanical demands. Due to the difference in the pattern of loading, we hypothesized that there are differences in bone remodeling rates between the maxillary and mandibular alveolar processes. Furthermore, in a canine model, the alveolar process of teeth that lack contact (e.g., second premolars) would have a different turnover rate than bone supporting teeth with functional contact (e.g., first molars). Six skeletally mature male dogs were given a pair of calcein labels. After sacrifice, specimens representing the anterior and posterior locations of both jaws were prepared for examination by histomorphometric methods to evaluate the bone volume/total volume (BV/TV; %), bone volume (mm(2)), mineral apposition rate (MAR; mu m/day), and bone formation rate (BFR; %/year) in the alveolar process. There were no significant differences (P > 0.05) in the BV/TV within the jaws. The bone volume within the alveolar process of the mandible was 2.8-fold greater than in the maxilla. The MAR was not significantly different between the jaws and anteroposterior locations. However, the BFR was significantly (P < 0.0001) greater in the mandible than in the maxilla. The anterior location had higher (P = 0.002) remodeling than the posterior location in the maxilla but not in the mandible. While there was a greater bone mass and increased remodeling in the mandible, no remodeling gradient in the coronal-apical direction was apparent in the alveolar process. Bone adaptation probably involves a complex interplay of bone turnover, mass, and architecture.