Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates.
Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates.
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DOI：
10.1111/ejn.12805
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Barth AL
中科院分区：
文献类型：
--
作者：
Glazewski S;Barth AL
虽然新皮层感觉神经元的阈下输入是广泛调谐的，但尖峰输出受到更多限制。这些阈下输入为刺激强度依赖性改变其尖峰输出以及经验依赖性可塑性改变放电特性提供了基质。在这里，我们研究了不同的刺激强度如何修改的个别神经元的放电输出在2/3层的小鼠桶皮质。降低刺激强度超过30倍的范围内降低了主要的胡须刺激引起的放电率，并减少了整体规模的反应合奏胡须unprived动物。然后，我们研究了这些反应是如何改变后，单胡须的经验（SWE）。经过7天的SWE，在最高的刺激强度备用胡须刺激的反应的平均幅度没有改变。然而，较低强度的胡须刺激显示，与对照组动物相比，平均放电输出增加了10倍以上。此外，在控制条件下，只有15%的神经元在低刺激强度下表现出任何放电，而SWE后超过70%的神经元。然而，仅在最高刺激强度下才检测到在紧邻的周围表示中测量的响应变化。总体而言，这些数据表明，测量经验依赖的变化，在尖峰输出的新皮层神经元是高度依赖于刺激强度。
Although subthreshold inputs of neocortical sensory neurons are broadly tuned, the spiking output is more restricted. These subthreshold inputs provide a substrate for stimulus intensity-dependent changes their spiking output, as well as for experience-dependent plasticity to alter firing properties. Here we investigated how different stimulus intensities modified the firing output of individual neurons in layer 2/3 of the mouse barrel cortex. Decreasing stimulus intensity over a 30-fold range lowered the firing rates evoked by principal whisker stimulation and reduced the overall size of the responding ensemble in whisker-undeprived animals. We then examined how these responses were changed after single-whisker experience (SWE). After 7 days of SWE, the mean magnitude of response to spared whisker stimulation at the highest stimulus intensity was not altered. However, lower-intensity whisker stimulation revealed a more than 10-fold increase in mean firing output compared with control animals. Also, under control conditions, only ∽15% of neurons showed any firing at low stimulus intensity, compared with more than 70% of neurons after SWE. However, response changes measured in the immediately surrounding representations were detected only for the highest stimulus intensity. Overall, these data showed that the measurement of experience-dependent changes in the spike output of neocortical neurons was highly dependent upon stimulus intensity.
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影响因子：
2.5
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影响因子：
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